Canine testicular tumors: correlation between histologic pattern and immunohistochemical markers

• Grant number: 11/16025-7
• Support Opportunities: Scholarships in Brazil - Master
• Start date: May 01, 2012
• End date: February 28, 2014
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Pathology
• Principal Investigator: Gisele Fabrino Machado
• Grantee: Janete Madalena da Silva
• Host Institution: Faculdade de Medicina Veterinária (FMVA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

The study of canine testicular tumors, as well as other modifications of the male reproductive tract are little explored in Brazil. The testicular neoplasms, are mostly incidental findings at necropsy, or testes originating from elective castration. In humans aged 25-35 years, testicular neoplasms characterize about 25% of malignancies diagnosed in men. In dogs, cancer of the testis are described usually as benign, although may metastasize or show features of malignancy with increasing age of the animal. However, the longevity of pets and owners' concern in relation to welfare of older animals, induce in a search of diagnostic methods more effective, and in necessity of better understanding the behavior of the neoplasm in this species. Based on the scarce literature data and the variation of the same behavior in relation to cancer of the reproductive tract of human and animal and also the similarity of testicular physiology in both species, we expect to increase the information about the canine testicular tumors, using markers for a more accurate histological classification and for improve the prognosis, once the simultaneous evaluation of different parameters, and verification of correlation between them can provide more meaningful results on the behavior and prognosis of testicular neoplasms. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SILVA, Janete Madalena da. Expressão imuno-histoquímica de KI-67, COX-2, MMP-9 e P53 nos tumores testiculares caninos. 2014. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária. Araçatuba Araçatuba.