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White Matter Evaluation with Diffusion Magnetic Resonance Imaging Techniques at High Field Strength and Multiparametric Correlation with Volumetry and Phosphorus Spectroscopy in Patients with Epilepsy and Malformations of Cortical Development

Grant number: 12/00398-1
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): May 01, 2012
Effective date (End): July 31, 2015
Field of knowledge:Health Sciences - Medicine - Medical Radiology
Principal Investigator:Claudia da Costa Leite
Grantee:Celi Santos Andrade
Host Institution: Instituto de Radiologia (INRAD). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated scholarship(s):13/15552-9 - White matter evaluation with diffusion magnetic resonance imaging techniques a high field strength and multiparametric correlation with volumetry and phosphorus spectroscopy in patients with epilepsy and malformations of cortical development, BE.EP.PD


Malformations of cortical development (MCD) result from disturbances in the complex process of development of the human cerebral cortex, and are frequently associated with severe epilepsy and neurodevelopment disorders. Currently, the multiplanar study with high resolution magnetic resonance (MR) imaging is the cornerstone in the evaluation of patients with epilepsy. Modern imaging techniques have improved not only the ability to detect and characterize the cortical malformations, but also led to the recognition of associated functional abnormalities that are far beyond the visualized structural lesions.The MCD can affect both the cortical gray matter and the subcortical white matter, and can be either focal or diffuse in the brain. New MR techniques based on the principles of diffusion and anisotropy can provide information about the anatomy, connectivity and organization of white matter tracts in the human brain in vivo.Multiparametric analysis of brain connectivity data (diffusion tensor imaging) with other advanced MR techniques of morphometry (volumetry) and metabolic analysis (phosphorus spectrosocopy), as well as correlation with clinical and electroencephalographic data will bring up a new global scenario of morphofunctional assessment of patients with MCD. These modalities have the potential to further characterize the macro and microstructure of the brain, aiding in the understanding of epileptogenesis.The research proposed in this project aims to provide innovative data about the structural and functional organization of the brain in patients with epilpesy and MCD, using advanced computational processing of high field MR images.

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CELI SANTOS ANDRADE; GABRIEL SCARABÔTOLO GATTÁS; ANA LUISA ROSAS; CLAUDIA DA COSTA LEITE. Telangiectasia capilar cerebral gigante sintomática. Arquivos de Neuro-Psiquiatria, v. 73, n. 1, p. 66-67, . (12/00398-1)
ANDRADE, CETI S.; LEITE, CLAUDIA C.; OTADUY, MARIA C. G.; LYRA, KATARINA P.; VALENTE, KETTE D. R.; YASUDA, CLARISSA L.; BELTRAMINI, GUILHERME C.; BEAULIEU, CHRISTIAN; GROSS, DONALD W.. Diffusion abnormalities of the corpus callosum in patients with malformations of cortical development and epilepsy. Epilepsy Research, v. 108, n. 9, p. 1533-1542, . (12/00398-1, 05/56464-9)
ANDRADE, CELI SANTOS; GARCIA OTADUY, MARIA CONCEPCION; RAMOS VALENTE, KETTE DUALIBI; PARK, EUN JOO; KANAS, ALEXANDRE FLIGELMAN; MOREIRA DA SILVA FILHO, MAURICIO RICARDO; TSUNEMI, MIRIAM HARUMI; LEITE, CLAUDIA COSTA. Widespread pH abnormalities in patients with malformations of cortical development and epilepsy: A phosphorus-31 brain MR spectroscopy study. BRAIN & DEVELOPMENT, v. 36, n. 10, p. 899-906, . (12/00398-1)
COSTA DE FREITAS, RICARDO MIGUEL; ANDRADE, CELI SANTOS; MENDES PEREIRA CALDAS, JOSE GUILHERME; TSUNEMI, MIRIAM HARUMI; FERREIRA, LORRAINE BRAGA; ARANA-CHAVEZ, VICTOR ELIAS; CURY, PATRICIA MALUF. Image-Guided Cryoablation of the Spine in a Swine Model: Clinical, Radiological, and Pathological Findings with Light and Electron Microscopy. CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, v. 38, n. 5, p. 1261-1270, . (11/51222-8, 12/00398-1)
COSTA DE FREITAS, RICARDO MIGUEL; ANDRADE, CELI SANTOS; MENDES PEREIRA CALDAS, JOSE GUILHERME; KANAS, ALEXANDRE FLIGELMAN; CABRAL, RICHARD HALTI; TSUNEMI, MIRIAM HARUMI; CERVANTES RODRIGUEZ, HERNAN JOEL; RABBANI, SAID RAHNAMAYE. Validation of cone-beam computed tomography and magnetic resonance imaging of the porcine spine: a comparative study with multidetector computed tomography and anatomical specimens. SPINE JOURNAL, v. 15, n. 5, p. 992-999, . (12/00398-1, 11/51222-8)
CELI SANTOS ANDRADE. Espectroscopia de fósforo por ressonância magnética em malformações do desenvolvimento cortical. Arquivos de Neuro-Psiquiatria, v. 71, n. 7, p. 498-498, . (05/56464-9, 12/00398-1)
RIMKUS, CAROLINA DE MEDEIROS; ANDRADE, CELI SANTOS; LEITE, CLAUDIA DA COSTA; MCKINNEY, ALEXANDER M.; LUCATO, LEANDRO TAVARES. Toxic Leukoencephalopathies, Including Drug, Medication, Environmental, and Radiation-Induced Encephalopathic Syndromes. SEMINARS IN ULTRASOUND CT AND MRI, v. 35, n. 2, p. 97-117, . (12/00398-1)

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