Advanced search
Start date
Betweenand
Related content

EXPRESSION OF MATRIX METALLOPROTEINASE-2 AND METALLOPROTEINASE-9 IN CEREBROSPINAL FLUID AND SERUM OF DOGS (CANIS FAMILIARIS) NATURALLY INFECTED BY CANINE DISTEMPER VIRUS.

Grant number: 12/05019-9
Support type:Scholarships in Brazil - Master
Effective date (Start): May 01, 2012
Effective date (End): March 31, 2014
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal researcher:Márcia Ferreira da Rosa Sobreira
Grantee:Caroline Godoi Aoki
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

Canine distemper is an important infectious disease with high mortality rate and multi-systemic involvement, including central nervous system. The demyelinating leukoencephalitis is the primary neuropathological alteration observed and the pathogenesis is not well understood. The disruption in the blood-brain barrier (BBB) with viral penetration and leukocyte infiltration are critical step in the development of demyelinating encephalitis. In humans beings and animals with similar neuropathological changes, the matrix metalloproteinases (MMPs) and especially -2 and -9 has been appointed as agents that destabilizing the integrity of the BBB. Thus, in order to determine the involvement of MMPs 2 and 9 in breakdown of the BBB in dogs with distemper encephalitis, this study have the main scope to determine the expression of MMP by gelatin-zymography in serum and cerebrospinal fluid of healthy dogs (G1, n = 10) and dogs with spontaneous canine distemper encephalitis (G2, n = 10). Moreover, the biochemical and cytological CSF parameters will be determined to obtain more information about the BBB's integrity.

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
AOKI, Caroline Godoi. Metaloproteinases de matriz 2 e 9 no líquido cefalorraquidiano e soro de cães naturalmente infectados pelo vírus da cinomose. 2014. Master's Dissertation - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências Agrárias e Veterinárias..

Please report errors in scientific publications list by writing to: cdi@fapesp.br.