| Grant number: | 12/03025-1 |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| Start date: | July 01, 2012 |
| End date: | April 30, 2015 |
| Field of knowledge: | Biological Sciences - Physiology - Physiology of Organs and Systems |
| Principal Investigator: | Lucia da Conceição Andrade |
| Grantee: | Talita Rojas Cunha Sanches |
| Host Institution: | Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
Abstract The Klotho gene encodes a single transmembrane protein that is expressed in kidney and other tissues. This protein is a cofactor for the action of fibroblast growth factor 23, thus having a critical role in metabolism of phosphorus. Recent studies demonstrated that Klotho plays a renoprotective effect in chronic glomerulopathies and kidney ischemia/reperfusion injury. Gene knockout animals for Klotho present hypercalcemia and hyperphosphatemia, increased excretion of calcium, in addition to increased resorption of calcium from intestine. These findings are mainly due to higher concentration of 1,25 vitamin D found in these animals. It has been was also shown that serum levels of antidiuretic hormone and aldosterone are increased in animals knockout for Klotho gene. Researchers have shown that heterozygous animals for the gene had a lower volemia than wild-type animals, suggesting depletion. The heterozygous animals also have lower blood pressure levels when compared to wild-type animals. So we propose to study the balance of sodium and water in animal knockouts and heterozygotes for the gene Klotho. | |
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