Expression of the enzyme indoleamine-2 ,3-dioxygenase in rainbow trout (Oncorhynchus mykiss)

• Grant number: 12/04738-1
• Support Opportunities: Scholarships in Brazil - Master
• Start date: July 01, 2012
• End date: May 31, 2014
• Field of knowledge: Agronomical Sciences - Veterinary Medicine
• Principal Investigator: José Roberto Kfoury Júnior
• Grantee: Fernanda Cardoso
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Indoleamine - 2,3 - dioxygenase (IDO) is an enzyme that catabolizes tryptophan, an essential amino acid necessary for T cells proliferation, therefore compromising its activity (BARKSDALE et al., 2004). IDO is expressed by several types of cells, including monocytes-derived macrophages and dendritic cells (MUNN et al., 2004). Evaluating the presence of IDO in blood cells and organs of rainbow trout may show the existence of regulatory mechanisms of the immune response in this species, thus contributing to the phylogenetic analysis of the immune system in vertebrates, particularly in fish.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CARDOSO, Fernanda. Expression of the enzyme indoleamine-2,3-dioxygenase in Rainbow Trout (Oncorhynchus mykiss). 2014. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) São Paulo.