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| Author(s): |
Fernanda Cardoso
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) |
| Defense date: | 2014-10-03 |
| Examining board members: |
José Roberto Kfoury Junior;
Patricia Cristina Baleeiro Beltrao Braga;
Ricardo Shohei Hattori
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| Advisor: | José Roberto Kfoury Junior |
| Abstract | |
The indoleamine 2,3-dioxygenase (IDO) is an enzyme that catabolizes the amino acid tryptophan, leading to inhibition of T lymphocyte proliferation by exhaustion of this amino acid in the environment, or by induction via the catabolites inducing apoptosis. In mammals, this enzyme acts on various conditions such as pregnancy, infections, chronic inflammation, transplantation and tumors, being recognized as an authentic immune regulator. Recent studies have identified the presence of homologous IDO in older phylogenetically related species molecules, the placental mammals, and the role of early IDO is not fully elucidated, it is known that in fungi and bacteria the role of IDO is limited to tryptophan metabolism for energy, and is function in lower vertebrates is still not well understood. This study aims to investigate the presence of IDO in peripheral blood cells and hematopoietic organs of rainbow trout, thereby contributing to the phylogenetic study of the immune system in vertebrates, particularly in fish. The expression of IDO was observed in the inner region of small blood vessels in the head kidney, spleen, liver and peripheral blood cells, mainly in monocytes and lymphocytes. The restricted localized expression of IDO in these tissues and cells, as occurred in mammals, may suggest a first evidence for a putative role of this enzyme in the immune system in rainbow trout. (AU) | |
| FAPESP's process: | 12/04738-1 - Expression of the enzyme indoleamine-2 ,3-dioxygenase in rainbow trout (Oncorhynchus mykiss) |
| Grantee: | Fernanda Cardoso |
| Support Opportunities: | Scholarships in Brazil - Master |