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Population dynamics of Anopheles darlingi by genotyping microssatellite in Acrelândia- AC - Brazil

Grant number: 12/04881-9
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): January 01, 2013
Effective date (End): May 31, 2016
Field of knowledge:Biological Sciences - Parasitology - Entomology and Malacology of Parasites and Vectors
Principal Investigator:Paulo Eduardo Martins Ribolla
Grantee:Melina Aulino Campos de Lima
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated scholarship(s):14/09461-3 - Anopheles darlingi population dynamics using microsatellite and ddRADseq in rural settlements in Acrelândia- Acre, Brazil, BE.EP.DD


Background Malaria is one of the most important tropical diseases in the world. WHO data report a total of 106 malaria-endemic countries and 151 million estimated cases in 2009. In South America, there are a high number of disease notifications in Brazil, Colombia, Peru, Venezuela, Suriname and Bolivia. These countries have large tracts of Amazon rainforest, South American biome and habitats for many Anopheles species that have high potential to be malaria vectors. Brazil has the largest number of malaria cases and malaria-related deaths in the Americas, and 15% of its population lives in at-risk areas, which are concentrated in the states of the Amazon Basin, with an average of 500 thousand notifications per year]. The strategies and targets for malaria control include diagnosis, disease treatment and prevention by mosquito control. Therefore, understanding the biology and behavior of the vector is extreme importance for efficient control of the disease. Anopheles darlingi is the major vector of malaria in Brazil. There are two main factors that may have contributed to this ability: the species is highly susceptible to the Plasmodium sp. that infect humans and demonstrates anthropophilic behavior. With respect to its biology and development, the larvae utilizes commonly water reservoirs close to houses as breeding grounds: lakes, margin rivers, streams and flooding areas, which are shaded or partly shaded, and mats of floating debris and vegetation. Human presence in the Peruvian Amazon influences the creation of new breeding sites via impoundment and creation of large lakes for fish farming. Various factors that change the habitat and performance of An. darlingi, mainly due to human interventions, have led us to research an intraspecies difference between the populations. Forest degradation, increased housing in the local forest and climate changes are strong influences on Anopheles populations. Therefore, it is necessary to obtain tools to identify and characterize the intraspecies variability in An. darling. The aim of this study is to understand Anopheles darling population structure at a micro-geographic scale. Mosquito populations from several settlements areas around Acrelândia will be study with the utilization of microsatellites. Influence of geographic aspects will be characterized and data on population structure will be linked to epidemiological data on malaria at this area (AU)

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
LIMA, Melina Aulino Campos de. Genetic heterogeneity of Anopheles darlingi and its implications for malaria epidemiology. 2016. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Botucatu Botucatu.

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