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Study of biological activities induced by Bothrops fonsecai snake venom and the uso of commercial bothropic antivenom as a pharmacological tool.

Grant number: 12/06165-9
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): July 01, 2012
Effective date (End): April 30, 2014
Field of knowledge:Biological Sciences - Pharmacology - Autonomic Pharmacology
Principal Investigator:Lea Rodrigues Simioni
Grantee:Rita de Cássia de Oliveira Collaço
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated scholarship(s):12/24444-2 - Analysis of antibody-antigen interactions (venom: antivenom) using size-exclusion high-performance liquid chromatography, BE.EP.MS


Bothropic snake venoms are a complex mixture of substances with different properties (mainly proteolytic, hemorrhagic and coagulant) that exert local action producing intense pain, edema, hemorrhage and necrosis, associated with systemic damage as coagulopathy, systemic bleeding and renal failure. Bothrops fonsecai, inhabits a limited area of Araucaria forest (Araucaria augustifolia) in Atlantic forest. Although poorly studied, this venom is constitued by essencial compounds to biological effects caused by snake venom as phospholipase, metalloprotease and serineprotease. The aim of this study is to evaluate the biological effects in vivo (hemorrhagic and edematogenic activity), ex vivo assays (neuromuscular and miotoxic activities) and in vitro assays (measurement of coagulant, phospholipase e creatine kinase activities) caused by B. fonsecai venom and its neutralization by comercial and specific antivenoms, such as the qualitative analisys of venom:antivenoms bidings by immunoblotting.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
COLLACO, RITA DE CASSIA O.; RANDAZZO-MOURA, PRISCILA; TAMASCIA, MARIANA L.; DA SILVA, IGOR RAPP F.; ROCHA, THALITA; COGO, JOSE C.; HYSLOP, STEPHEN; SANNY, CHARLES G.; RODRIGUES-SIMIONI, LEA. Bothrops fonsecai snake venom activities and cross-reactivity with commercial bothropic venom. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, v. 191, p. 86-100, . (12/06165-9, 12/24444-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
COLLAÇO, Rita de Cássia de Oliveira. Bothrops fonsecai snake venom biological effects and the use of commercial bothropic antivenom as pharmacological tool. 2014. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.

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