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Structural changes using the technique of voxel-based morphometry (VBM) in patients with Parkinson's Disease

Grant number: 12/05286-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2012
Effective date (End): May 31, 2015
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Anelyssa Cysne Frota D'Abreu
Grantee:Maria Cristina Arci Santos
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The earlier descriptions of Parkinson's disease (PD) were limited to its motor manifestations: tremor, rigidity and flexed posture. Years later, a cytoplasmatic inclusion was discovered, the Lewy bodies (LB), the mais pathological feature of the disease. The neostriatal dopamine deficiency in PD was only noted later. PD is defined by progressive degeneration of dopaminergic neurons of the nigrostriatal system and other neural networks caused by progressive loss of neuromelanin in the substantia nigra pars compacta (SNc) and many other subcortical nuclei associated with the deposition of Lewi's bodies. In 2002, based on some neuropathological findings Braak elegantly suggested that as the disease progresses, the accumulation of intracerebral LB, begins in the lower medulla and progresses in an ascending fashion towards the autonomic, somatomotor and limbic systems. Most previous studies using voxel-based morphometry (VBM) in patients with PD have made comparisons between patients with or without pre-determined symptoms, such as psychosis, dementia, or even tremor. Hence, it is justified to perform a larger study to make correlations between the clinical course and morphological changes in PD. The aim of this study is to compare patients with PD to a control group and evaluate the morphometric differences using voxel-based morphometry (VBM). All patients will be evaluated through a review of its history, complete neurological examination and application of validated scales for patients with PD. A voxel-based morphometry (VBM) is a global analysis of the brain and elucidates focal differences in different brain regions, using the statistical approach of the statistical parametric mapping. Correlations between the clinical course and morphological changes have not been definitively validated. The use of imaging techniques allows the study of changes in vivo and can confirm the findings previously suggested.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GUIMARAES, RACHEL PAES; ARCI SANTOS, MARIA CRISTINA; DAGHER, ALAIN; CAMPOS, LIDIANE SOARES; AZEVEDO, PAULA; PIOVESANA, LUIZA GONZAGA; DE CAMPOS, BRUNNO MACHADO; LARCHER, KEVIN; ZEIGHAMI, YASHAR; SCARPARO AMATO-FILHO, AUGUSTO C.; CENDES, FERNANDO; FROTA D'ABREU, ANELYSSA CYSNE. Pattern of Reduced Functional Connectivity and Structural Abnormalities in Parkinson's Disease: An Exploratory Study. FRONTIERS IN NEUROLOGY, v. 7, JAN 13 2017. Web of Science Citations: 6.
SANTOS, MARIA C. A.; CAMPOS, LIDIANE S.; GUIMARAES, RACHEL P.; PICCININ, CAMILA C.; AZEVEDO, PAULA C.; PIOVESANA, LUIZA G.; DE CAMPOS, BRUNNO MACHADO; SCARPARO AMATO-FILHO, AUGUSTO C.; CENDES, FERNANDO; D'ABREU, ANELYSSA. Does side of Onset influence the Pattern of cerebral atrophy in Parkinson's Disease?. FRONTIERS IN NEUROLOGY, v. 7, SEP 12 2016. Web of Science Citations: 4.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.