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Study of physical properties of giant vesicles in presence of oxidized lipids

Grant number: 12/06208-0
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): September 01, 2012
Effective date (End): December 31, 2012
Field of knowledge:Biological Sciences - Biophysics
Principal Investigator:Rosangela Itri
Grantee:Helena Couto Junqueira
Supervisor abroad: Carlos Manuel Venâncio Marques Serra
Home Institution: Instituto de Física (IF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Local de pesquisa : Institut Charles Sadron (ICS), France  
Associated to the scholarship:11/00963-8 - Photosensitization mechanisms in lipid membranes: the role of lipid hydroperoxides and the lipid rafts formation, BP.PD

Abstract

The oxidative stress cause the lipid peroxidation that cause damage in the membrane and triggers signal cascades inducing apoptosis. The aim of this project is study the role of lipid hydroperoxide and the lipid raft formation. The studies will be performed in binary and ternary mixtures of lipids in presence of oxidized lipids. The informations about domain formation and membrane properties, as area increase, permeability and elasticity will help us to understand the role of lipid hidroperoxide in the photosensitization mechanisms. (AU)