Morphological features of the truncal valve and of the other associated abnormalities in common arterial trunk

• Grant number: 12/06735-0
• Support Opportunities: Scholarships abroad - Research Internship - Scientific Initiation
• Start date: June 17, 2012
• End date: July 16, 2012
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Vera Demarchi Aiello
• Grantee: Gabriel Romero Liguori
• Supervisor: Yen Ho
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Institution abroad: Imperial College London, England
• Associated to the scholarship: 10/16811-0 - Histological morphology of the semilunar valves in common arterial trunk and its relationship with other morphological features of the anomaly., BP.IC

Abstract

Hearts with Common Arterial Trunk (CAT) may show dysplastic arterial valve, which appear to impact on early deaths and on the postoperative prognosis. The morphology of dysplastic leaflets is still poorly defined and usually described qualitatively in the literature as nonspecific fibrous thickening of their margins. Abnormalities of the coronary arteries and of the aortic arch arteries have also been described in CAT, but to date no study has sought to establish objective relations between the truncal valve abnormalities and other morphological features. Objective: Systematically assess, both qualitatively and quantitatively, alterations of the truncal valve and check for possible associations with coronary and aortic arch anomalies. Methods: Gross features of the coronary ostia (number, position and shape) and aortic arch will be annotated and confronted with the gross features of the truncal valve (number of leaflets, thickness and length). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LIGUORI, GABRIEL ROMERO; JATENE, MARCELO BISCEGLI; HO, SIEW YEN; AIELLO, VERA DEMARCHI. Morphological variability of the arterial valve in common arterial trunk and the concept of normality. HEART, v. 103, n. 11, p. 848-855, JUN 2017. (10/16663-0, 10/16811-0, 12/06735-0)