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Fatigue effect on gait of patients with Parkinson's disease: relationship with physical activity level.

Grant number: 11/05144-5
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2012
Effective date (End): July 31, 2013
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Lilian Teresa Bucken Gobbi
Grantee:Paulo Cezar Rocha dos Santos
Home Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil


Fatigue is considered a symptom of high incidence in patients with Parkinson's disease (PD), which may influence the walking. Physical activity counteracts the effects of PD and fatigue. However, the relationship between physical activity and fatigue and the influence of fatigue-inducing on gait parameters in PD patients compared with control subjects are not clear. To fill these gaps, two studies are proposed: A) Study 1 aimed to compare and correlate the subjective perception of fatigue with the physical activity level in PD patients and in individuals not affected by PD. Eighty subjects, 40 patients with PD and 40 subjects without PD, will participate in this study. The participants, within their groups, will be distributed in actives (20) and inactives (20) according to scores on the modified Baecke questionnaire for the elderly. The Multidimensional Fatigue Inventory will be used to verify the subjective perception of fatigue. The relationship between physical activity level and subjective perception of fatigue for each group will be observed through the correlation tests. Comparison of the subjective perception of fatigue will be conducted through analysis of variance with group and physical activity level as factors. B) Study 2 aims to analyze the effect of fatigue on kinematic, kinetic and electromyographic variables on free and adaptive gait parameters in PD patients and individuals not affected by PD, considering the level of physical activity. To do this, 40 subjects, 20 PD patients (10 active and 10 inactive) and 20 subjects without PD (10 active and 10 inactive) will be selected. Three attempts will be made to the conditions of free and adaptive walk before and after induction of fatigue, achieved by the task of sitting and standing on a chair. Kinematic, kinetic and EMG variables will be collected during the attempts. Analysis of variance will be conducted considering group and fatigue as factors and the physical activity level as a covariate. It is hoped that the results of this project will contribute to a better understanding about the control of locomotion and, therefore, to support the intervention in patients with PD.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
IGNACIO PEREIRA, VINICIUS ALOTA; BARBIERI, FABIO AUGUSTO; ZAGATTO, ALESSANDRO MOURA; ROCHA DOS SANTOS, PAULO CEZAR; SIMIELI, LUCAS; BARBIERI, RICARDO AUGUSTO; CARPES, FELIPE PIVETTA; BUCKEN GOBBI, LILIAN TERESA. Muscle Fatigue Does Not Change the Effects on Lower Limbs Strength Caused by Aging and Parkinson's Disease. Aging and disease, v. 9, n. 6, p. 988-998, DEC 2018. Web of Science Citations: 3.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SANTOS, Paulo Cezar Rocha dos. Efeito da fadiga no andar de pacientes com doença de Parkinson : relação com o nível de atividade física. 2013. 73 f. Master's Dissertation - Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Rio Claro)..

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