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Association between preoperative depressive symptoms and postoperative cognitive dysfunction in patients undergoing surgery under general anaesthesia.

Grant number: 11/22478-4
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2012
Effective date (End): July 31, 2013
Field of knowledge:Health Sciences - Medicine - Surgery
Principal researcher:Maria José Carvalho Carmona
Grantee:Letícia Maria de Araújo de Souza
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


INTRODUCTION AND OBJECTIVES: Among the many factors that relate to the occurrence and level of postoperative cognitive dysfunction, we find depression. Depression can occur before, during or after a surgical event, and depending on the moment it occurs it might refer to different causes and consequences. Little is known about this association, what makes relevant this research. This study aims to investigate the associations between postoperative cognitive dysfunction and the presence of depressive symptoms. MATERIALS AND METHODS: With the approval of the institutional ethics committee, 75 patients over the age of 60 years undergoing non cardiac surgery under general anesthesia will be evaluated. Tests of quality of life, depressive symptoms and a neuropsychological battery to assess general mental status, attention and perception, memory and executive skills will be performed. This battery defines the cognitive stability index, that is a longitudinal mesure of the cognitive status in repeated assessments which detect mood and cognition changes. These evaluations will be performed before surgery, and on the 3rd, 7th, 21st, 90th and 180th postoperative days. The collected data will be analyzed using analysis of variance for repeated measures for the parametric data or Mann-Whitney for the non parametric. The association between the occurrence of preoperative depressive symptoms and POCD will be evaluated by the chi-square test, considering significant p<0.05. The results will be submitted for publication in an appropriate scientific journal.Keywords: depression, cognitive dysfunction, general anesthesia.

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