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Functional connectivity in default mode network in patients with depression and/or anxiety symptoms post-stroke

Grant number: 13/23183-3
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): April 01, 2014
Effective date (End): January 31, 2016
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Li Li Min
Grantee:Jéssica Elias Vicentini
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Emotional and cognitive injuries are common after a stroke, a disease that is a leading cause of death in Brazil. Depression and anxiety are psychological disorders with a high incidence after the event and have a negative impact on the social reintegration, quality of life and patient recovery, and may even exacerbate disabilities related to stroke. Despite the growing interest in the phatophysiology, there are conflicting studies on the prevalence of depressive and anxiety symptoms over the stages (acute, sub acute and chronic), and there is no specific injured area to justify the appearance of these symptoms. It can be suggested, therefore, that the causes go beyond structural lesions, but there are changes in the functional connectivity of the brain. The neural network has been more associated with this framework is the Default Mode Network (DMN). Through functional Magnetic Resonance Imaging (fMRI) in resting state, it is possible to access the brain function noninvasively and have access to the operation of this network. The recovery after stroke appears to depend on the reorganization of the network. Furthermore, previous dysfunctions in DMN seem to be related to depressive and anxiety symptoms later. To our knowledge, there are no studies that investigate the functional connectivity of the DMN of patients after stroke in the first month and the sixth month, in order to understand whether changes in the network are able to influence depressive and anxiety symptoms and if the reorganization of this network can lead to changes in neuropsychological assessment. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VICENTINI, JESSICA ELIAS; WEILER, MARINA; MEIRA ALMEIDA, SARA REGINA; DE CAMPOS, BRUNNO MACHADO; VALLER, LENISE; LI, LI MIN. Depression and anxiety symptoms are associated to disruption of default mode network in subacute ischemic stroke. BRAIN IMAGING AND BEHAVIOR, v. 11, n. 6, p. 1571-1580, . (15/06163-4, 13/23183-3, 13/07559-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
VICENTINI, Jéssica Elias. Depression and anxiety symptoms are associated to disruption of Default Mode Network in subacute ischemic stroke. 2016. 72 f. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas.

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