| Grant number: | 11/15805-9 |
| Support Opportunities: | Scholarships in Brazil - Master |
| Start date: | September 01, 2012 |
| End date: | February 28, 2014 |
| Field of knowledge: | Biological Sciences - Microbiology - Applied Microbiology |
| Principal Investigator: | Jonas Contiero |
| Grantee: | Marcela Piassi Bernardo |
| Host Institution: | Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil |
Abstract The aim of this project is through a fed- batch fermentation, with the use of pH ( pH-stat) increase the efficiency of fermentation and avoid formation of plaster during production of lactic acid. For the production of L(+) lactic acid, by Lactobacillus rhamnosus B103 in batch will be use the optimized medium( 110g/L lactose, 90 ml/L corn step liquor, 2ml/L Tween 80 and 0,15 g/L manganese sulfate). Will be made five different types of fed- batch: simple batch, fed- batch with a constant flow, fed- batch by pulse, exponential fed-batch and fed-batch by pH stat. In all the experiments, samples will be withdrawn, each 6 hours, to kinetic evaluation of lactic acid fermentation. After determination of the best fed-batch process, will be made one fermentation using the best parameter and with the fermentation broth different purification methodologies will be evaluated: resin ion exchange, nanofiltration and conventional method. | |
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