|Support type:||Scholarships in Brazil - Master|
|Effective date (Start):||August 01, 2012|
|Effective date (End):||February 28, 2014|
|Field of knowledge:||Biological Sciences - Immunology|
|Principal researcher:||Cristina de Oliveira Massoco Salles Gomes|
|Grantee:||Ana Paula Nascimento de Lima|
|Home Institution:||Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil|
The effects of stress are constant factors and important components in one's life and cause relevant changes on the immune system. Dendritic cells (DCs) are antigen presenting cells with a unique ability to activate T lymphocytes. These cells are important elements of the link between innate and adaptive immune responses. However, the pathways involved in regulating these cells still remain unclear. Thus, this project aims to investigate the effects of restraint stress on the regulation of dendritic cells (DCs) in rats. DCs will be analyzed in the stage of differentiation, endocytic capacity and antigen presenting function.