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Effects of restraint stress on regulation of dendritic cells

Grant number: 12/09332-3
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2012
Effective date (End): February 28, 2014
Field of knowledge:Biological Sciences - Immunology
Principal researcher:Cristina de Oliveira Massoco Salles Gomes
Grantee:Ana Paula Nascimento de Lima
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The effects of stress are constant factors and important components in one's life and cause relevant changes on the immune system. Dendritic cells (DCs) are antigen presenting cells with a unique ability to activate T lymphocytes. These cells are important elements of the link between innate and adaptive immune responses. However, the pathways involved in regulating these cells still remain unclear. Thus, this project aims to investigate the effects of restraint stress on the regulation of dendritic cells (DCs) in rats. DCs will be analyzed in the stage of differentiation, endocytic capacity and antigen presenting function.

Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
LIMA, Ana Paula Nascimento de. Effects of acute restraint stress on phenotypic and functional characterization of dendritic cells in Balb/c mice. 2014. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia São Paulo.

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