Study of participation of Angiotensin II in cardiovascular dysfunction induced by chronic ethanol consumption

• Grant number: 12/10096-2
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2012
• End date: October 31, 2013
• Field of knowledge: Biological Sciences - Pharmacology - Cardiorenal Pharmacology
• Principal Investigator: Carlos Renato Tirapelli
• Grantee: Patrícia Passaglia
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The chronic consumption of ethanol results in significant changes in cardiac and circulatory functions, appearing as an important risk factor in developing cardiovascular diseases such as hypertension. In models of chronic consumption of ethanol was observed that the initial step for the ethanol-associated cardiovascular dysfunction involves the formation of reactive oxygen species (ROS), this process being mediated by the enzyme NAD (P) H oxidase. Angiotensin II (ANG II) activates NAD (P) H oxidase in the cardiovascular system and chronic consumption of ethanol induces activation of the renin angiotensin system (RAS). The quest for understanding the molecular mechanisms involved in cardiovascular effects of ethanol led to the study of the activation of MAPKs (mitogen-activated protein kinase) by ethanol since these proteins play an important role in intracellular signaling. The MAPKs are activated by different stimuli such as ROS, and ANG II. The hypothesis of this study is that the chronic consumption of ethanol stimulates the RAS which in turn induces the production of ROS (via activation of AT1 receptors) and activation of MAPKs. This process would lead to alterations in vascular reactivity and bioavailability of the NO as well as increased blood pressure. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PASSAGLIA, PATRICIA; CERON, CARLA S.; MECAWI, ANDRE S.; ANTUNES-RODRIGUES, JOSE; COELHO, EDUARDO B.; TIRAPELLI, CARLOS R.. Angiotensin type 1 receptor mediates chronic ethanol consumption-induced hypertension and vascular oxidative stress. VASCULAR PHARMACOLOGY, v. 74, p. 49-59, NOV 2015. (12/10096-2, 10/05815-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PASSAGLIA, Patrícia. Study of participation of angiotensin II in cardiovascular dysfunction induced by chronic ethanol consumption. 2014. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.