| Grant number: | 12/11479-2 |
| Support Opportunities: | Scholarships in Brazil - Master |
| Start date: | January 01, 2013 |
| End date: | December 31, 2014 |
| Field of knowledge: | Health Sciences - Medicine - Medical Clinics |
| Principal Investigator: | Ericka Barbosa Trarbach |
| Grantee: | Amanda Shinzato |
| Host Institution: | Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
Abstract Multinodular goiter (MNG) is defined as an enlargement of the thyroid gland that is characterized by heterogeneity in growth and function of thyroid follicular cells. It is a benign and very common disease. Constitutive activation of the phosphatidylinositol 3-kinase (PI3K) signal transduction pathway, including PTEN loss of expression, in follicular cells has been frequently involved in the cancer and goiter development in Cowden syndrome. Recently, was demonstrated that over expression of DREAM (downstream regulatory element antagonist modulator) provokes a marked enlargement of the thyroid gland in transgenic mice. Additionally, increased levels of DREAM protein were observed in human multinodular goiters, suggesting a novel etiopathogenic mechanism in nodular development in humans. The purpose of this project is to investigate the role of germinative mutations in PTEN and DREAM genes in etiology of MNG. The DREAM expression was also evaluate in patients with MNG. | |
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