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Systematic review of efficacy and safety of the endoscopic versus the microscopic transsphenoidal surgery in the treatment of acromegaly

Grant number: 12/14761-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2012
Effective date (End): February 28, 2014
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Vania dos Santos Nunes Nogueira
Grantee:Carla Maria de Marque Silva
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Among the treatment options for Acromegaly, trans-sphenoidal surgery is the first option in most cases. Microscopic transsphenoidal surgery is a widely accepted and highly effective therapy for pituitary adenomas. However, over the past decade, several centers have converted to an endoscopic transsphenoidal approach; suggesting that this technique provides more complete tumor resection and reduces complications. Studies comparing these two techniques of surgery sometimes indicate advantages to endoscopic surgery and sometimes the results were similar. In addition, the principal existing studies took into account the old criteria for Acromegaly. This study will evaluate the efficacy and safety of endoscopic versus microscopic trans-sphenoidal surgery in the treatment of Acromegaly. If possible, the results will be compared regarding the old criteria for cure (basal GH <2,5 ng / mL and normal IGF1) versus the current (basal GH <1 ng/mL and normal IGF1). For this, there will be a systematic literature review according to Cochrane methodology. When the data from more than one study are homogeneous and with similar clinical outcomes, they will be plotted in a meta-analysis.(AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BASTOS, RODRIGO V. S.; SILVA, CARLA MARIA D. M.; TAGLIARINI, JOSE VICENTE; ZANINI, MARCO ANTONIO; ROMERO, FLAVIO R.; BOGUSZEWSKI, CESAR LUIZ; NUNES, VANIA DOS SANTOS. Endoscopic versus microscopic transsphenoidal surgery in the treatment of pituitary tumors: systematic review and meta-analysis of randomized and non-randomized controlled trials. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 60, n. 5, p. 411-419, . (12/14761-0)

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