Neuroimmunoendocrine effects of acute exercise in individuals with spinal cord injury

• Grant number: 12/16086-9
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: November 01, 2012
• End date: August 31, 2016
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Marco Túlio de Mello
• Grantee: Eduardo da Silva Alves
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

According to World Health Organization, disability is the term used to define the absence or dysfunction of a psychic, physiological or anatomical structure. It is estimated that 15% of the world's population has some form of disability. This condition represents a major socioeconomic problem mainly due to the high incidence and costs involved in the diagnosis, treatment, rehabilitation and support of these patients,. In addition to the changes imposed by the locomotor and sensory spinal cord injury, this population has several hormonal, metabolic and immunological diseases. Exercise is a nonpharmacologic therapy that represents a major form of treatment for the rehabilitation of individuals with spinal cord injury. It is known for anti-inflammatory action and, also, to promote changes in the metabolism of carbohydrates and fats In this context, the aim of this study is to evaluate the effects of different intensities of exercise on inflammatory, immunological and biochemical parameters in individuals with spinal cord injuries. The sample will consist of 20 male volunteers with complete spinal cord injury between the vertebrae T7 to L1. The volunteers will perform three sessions of exercise at different intensities, but with the same energy expenditure. Blood samples will be harvested immediately before and after the exercise sessions in order to analyze the neuroimmunoendocrine parameters. We hypothesize that acute exercise causes an increase in the sympathetic activity, in a training-intensity dependent manner, promoting an increase in plasma catecholamines and, consequentely, a modulation at the neuroimmunoendocrine axis in individuals with spinal cord injury.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ALVES, EDUARDO S.; SANTOS, RONALDO V.; DA SILVA, FRANCIELE RUIZ; LIRA, FABIO S.; LIMA, GISCARD; OYAMA, LILA; TUFIK, SERGIO; DE MELLO, MARCO TULIO. Effects Of Different Intensities Of Acute Exercise On Systemic Markers Of Inflammation In Paraplegic Athletes.. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 47, n. 5, p. 1-pg., 2015-05-01. (12/16086-9)