Hemodynamics of intracranial aneurysm

• Grant number: 12/15033-9
• Support Opportunities: Scholarships abroad - Research Internship - Scientific Initiation
• Start date: January 01, 2013
• End date: January 31, 2013
• Field of knowledge: Health Sciences - Medicine - Medical Radiology
• Principal Investigator: Dorotéia Rossi Silva Souza
• Grantee: Thais de Brito Maluf
• Supervisor: Alain Bonafe
• Host Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil
• Institution abroad: Institute for Neurosciences Montpellier (INM), France
• Associated to the scholarship: 11/12414-9 - Vascular Endothelial Growth Factor: Genetic Polymorphisms in Patients with Familial Intracranial Aneurysm and Its Relation to Hypertension and Diabetes Mellitus, BP.IC

Abstract

Intracranial aneurysms (IA) are pathological dilations in cerebral arteries, causing significant morbidity and mortality. The hemorrhagic stroke (HS) is in breach of IA, or associated with other vascular malformations. The bleeding can cause traumatic injury to the tissue and edema around the hemorrhage, increased intracranial pressure, with progression of tissue damage. In this context, stand out the physical characterization of the aneurysm, as risk factors associated with rupture of these, and is composed of hemodynamics of the vessel wall, the morphology and structure of the aneurysm. Monitor service routine Interventional Neuroradiology at the Institute of Neurosciences of Montpellier and the new learning approach for aneurysm volume quantification using 3D rotational angiograms. Will be carried out visits to the infirmary every morning, monitoring of imaging (cerebral angiography), surgical procedures (embolizations - diagnosis and treatment), case discussion and analysis of measurements (hemodynamics) of intracranial aneurysm. The knowledge gained will be applied to the neurosurgery service of the School Hospital / Medical School of Sao Jose do Rio Preto (FUNFARME/FAMERP) for possible junction with genetic analysis of intracranial aneurysms already undertaken by that service. Statistical analysis include Kruskal-Wallis test, Bonferroni's correction, paired T-test. The significance threshold is 0.05. (AU)