| Grant number: | 12/12847-5 |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| Start date: | November 01, 2012 |
| End date: | October 31, 2016 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry - Analytical Chemistry |
| Principal Investigator: | Luiz Alberto Colnago |
| Grantee: | Paulo Falco Cobra |
| Host Institution: | Embrapa Instrumentação Agropecuária. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA). Ministério da Agricultura, Pecuária e Abastecimento (Brasil). São Carlos , SP, Brazil |
| Associated scholarship(s): | 15/02534-8 - Application of NMR-Based metabolomics to biomedical problems, BE.EP.DR |
Abstract The study of biological systems in a holistic way (systems biology) has become a necessity to provide qualitative and quantitative descriptions of emergent properties of the system as a whole. Among these are studies of metabolic profile, called the metabolome and metabonome. The Nuclear Magnetic Resonance spectroscopy (NMR) is one of the most important technique used in the study of metabolic profile as a quantitative, highly reproducible and non-selective technique. Thus, the aim of this project is the analysis of metabolomic and metabonomic profile of the leishmaniasis's causative agent , Leishmania major and L. Friedling donovani by NMR.Leishmaniasis is a disease caused by flagellate protozoa of the genus Leishmania, the family Trypanosomatidae, transmitted through sandflie bites . It has two main variations: the visceral and cutaneous leishmaniasis. The World Health Organization estimates that 350 million people are in areas at risk of contracting some form of leishmaniasis, 12 million are currently infected and 1.6 million new infections occur every year. | |
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