Zinc and Magnesium Organometallic bases complexed with lithium chloride were recently introduced in the literature and show great potential in the functionalization of several aromatic rings and heterocyclic. However, their reactivity towards important substrates has not yet been properly studied. This is the case of nitriles, which, although being a large and wide field of applications in organic synthesis, have received little attention from researchers working in the area. Thus, the main aim of this project is to develop methodologies for the preparation of highly functionalized nitriles and can be applied to the synthesis of bioactive molecules.In order to demonstrate the importance of the synthetic methodology, we intend to apply these in the synthesis or structural modification of bioactive molecules, such as venlafaxine, an antidepressant, and pyrimethamine, a substance that has been used to treat malaria. Moreover, the novel nitriles to be synthesized in this project could be tested by groups of the Faculty of Pharmaceutical Sciences of Ribeirão Preto - USP active in the biological evaluation of natural and synthetic substances.The proposals here presented are part of the project "Development of New Synthetic Methods Aimed at Preparation of Bioactive Molecules", approved by FAPESP through the Young Researcher modality with the objective of gather research groups that work with modern themes and with international integration.
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