Cyclization reaction of Acetyl- and Ethylpyrrolidin-2-one with Potassium Organotrifluoroborate Salts

• Grant number: 12/17954-4
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: December 01, 2012
• End date: November 30, 2015
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Helio Alexandre Stefani
• Grantee: Bakhat Ali
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 12/00424-2 - Synthesis of small libraries using potassium Organotrifluoroborates in Suzuki-Miyaura reactions, AP.TEM

Abstract

The main theme of this project is the use of potassium organotrifluoroborate salts, in some stages, aiming at the development of addition reactions to acyliminium ions,and cyclization reactions catalyzed by Lewis acids, to obtain heterocyclic compounds.

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

STEFANI, HELIO A.; ALI, BAKHAT; FERREIRA, FERNANDO P.. Ultrasound-assisted addition of alcohols to N-acyliminium ions mediated by In(OTf)3 and synthesis of 1,2,3-triazoles. Tetrahedron Letters, v. 55, n. 23, p. 3400-3405, JUN 4 2014. (12/00424-2, 12/17954-4)

ALI, BAKAT; KUPA, LEONARD D. KANDA; HELUANY, CINTIA S.; DREWES, CARINE C.; VASCONCELOS, STANLEY N. S.; FARSKY, SANDRA H. P.; STEFANI, HELIO A.. Cytotoxic effects of a novel maleimide derivative on epithelial and tumor cells. BIOORGANIC CHEMISTRY, v. 72, p. 199-207, JUN 2017. (13/17960-7, 12/17954-4, 12/00424-2, 10/19802-1, 14/07328-4)

ALI, BAKHAT; VASCONCELOS, STANLEY N. S.; SHAMIM, ANWAR; ZUKERMAN-SCHPECTOR, J.; STEFANI, HELIO A.. Synthesis of 1-((4-methoxyphenyl)-3-alkynes)-1H-pyrrole-2,5-diones and functionalization to triazoles. ARABIAN JOURNAL OF CHEMISTRY, v. 10, n. 4, p. 500-508, MAY 2017. (12/00424-2, 12/17954-4, 13/17960-7)

STEFANI, HELIO A.; FERREIRA, FERNANDO P.; ALI, BAKHAT; PIMENTA, DANIEL C.. Synthesis of functionalized N-triazolyl maleimides. Tetrahedron Letters, v. 55, n. 31, p. 4355-4358, JUL 30 2014. (12/00424-2, 12/17954-4)

SHAMIM, ANWAR; BARBEIRO, CRIATIANE S.; ALI, BAKHAT; STEFANI, HELIO A.. Synthesis of Stannyl-Substituted D-Glucal Derivatives via Palladium-Catalyzed Regioselective Hydrostannation and Their Synthetic Applications. CHEMISTRYSELECT, v. 1, n. 18, p. 5653-5659, NOV 1 2016. (12/00424-2, 12/17954-4)

ALI, BAKHAT; SHAMIM, ANWAR; VASCONCELOS, STANLEY N. S.; STEFANI, HELIO A.. Synthesis and applications of 4-substituted 1-(4-iodophenyl)pyrrolidine-2,5-diones. Tetrahedron Letters, v. 56, n. 28, p. 4234-4241, JUL 8 2015. (12/00424-2, 12/17954-4)

ALI, BAKHAT; ZUKERMAN-SCHPECTOR, JULIO; FERREIRA, FERNANDO P.; SHAMIM, ANWAR; PIMENTA, DANIEL C.; STEFANI, HELICI A.. Lewis-acid catalyzed N-acyliminium ion cyclodimerization: synthesis of symmetrical 1,4-dioxanes. Tetrahedron Letters, v. 56, n. 9, p. 1153-1158, FEB 25 2015. (12/00424-2, 12/17954-4, 11/11499-0)