| Grant number: | 12/18623-1 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | November 01, 2012 |
| End date: | August 31, 2013 |
| Field of knowledge: | Health Sciences - Medicine - Medical Clinics |
| Principal Investigator: | Carmen Silvia Passos Lima |
| Grantee: | Erika Stocco dos Santos |
| Host Institution: | Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
Abstract The squamous cell carcinoma (SCC) of the oropharynx (OR) is a serious global health problem. It is well known that individuals with habits of smoking and drinking alcohol for many years are more likely to develop SCCOR. There are genes that play a role in the regulation pathways that control cellular responses to DNA damage caused by reactive oxygen species formed by the combustion of tobacco and ingestion of alcohol. In addition, these genes are polymorphic in humans. However, little is known roles of the polymorphisms OGG1 c.977C> G, APEX1 c.444T> G, and XRCC1 c.580C> T, c.839G> A, c.1196A> G and c.-77C > T, related to DNA base excision repair, in the occurrence of SCCOR, as well as its clinical manifestations. Based on these, these were the objectives of this study. Will be assessed 200 patients with SCC of the OR and 200 controls matched to patients by age, sex and skin color, in the Oncology Clinic Ambulatory of the Clinical Hospital of UNICAMP. Clinical information will be obtained from patient charts by the researcher responsible for the study. The genotyping will be performed by polymerase chain reaction and restriction enzyme digestion. The statistical significance of differences between groups will be calculated using the exact probability test or Fisher's chi-square test and multiple logistic regression. The determinations of risk of occurrence of SCCOR, that patients and controls underwent, will be obtained through the odds ratios (ORs) and calculated assuming a confidence interval of 95%. We believe the results of this study may contribute to a better understanding of the etiology and pathophysiology of SCCOR, to identify groups of individuals at high risk for the disease, which receive merit special attention for prevention and early diagnosis. | |
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