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Analysis of intracerebroventricular injection of melatonin in feeding behavior and changes in signal transmission of insulin in liver, muscle and adipose tissues in the experimental diurnal model Arvicanthis ansorgei

Grant number: 12/20229-0
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): May 01, 2013
Effective date (End): April 30, 2014
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:José Cipolla Neto
Grantee:Rosana Fátima Dantas Ferreira
Supervisor abroad: Etienne Challet
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo, SP, Brazil
Local de pesquisa : Université de Strasbourg, France  
Associated to the scholarship:10/12947-4 - Effects of central melatonin replacement therapy in older animals - changes in insulin signal transmission in the hypothalamus, liver, muscle and adipose tissue, BP.DR


Melatonin is a hormone produced by the pineal gland during the night. As your circulatory rhythms are robust and predictable they are strong synchronizers for the expression of several physiological processes, including energy metabolism. Studies in our group have shown that melatonin replacement orally in older animals, regulates insulin responses, reduces food intake due to body weight lost. Some studies show that central injection of melatonin is more effective than replacement in periphery in glucose regulation (greater hypoglycemic action). Furthermore, studies in our group have shown that replacement of melatonin orally regulates insulin responses and reduces food intake and body weight in aged animals. Since there is evidence in the literature that melatonin may act centrally regulating energy metabolism, it is intended with this work evaluate the effects of the injection of melatonin in diurnal rats, by reverse microdialysis in the third ventricle, on feeding behavior, variation of body weight and peripheral insulin response. These metabolic parameters are well known in animals of nocturnal activity and very little is known about how they happen in diurnal rodents. It is proposed with this project the evaluation of these metabolic parameters in experimental diurnal animal Arvicanthis ansorgei. (AU)