| Grant number: | 12/20348-9 |
| Support Opportunities: | Scholarships in Brazil - Master |
| Start date: | March 01, 2013 |
| End date: | February 28, 2015 |
| Field of knowledge: | Biological Sciences - Biophysics - Biophysics of Processes and Systems |
| Principal Investigator: | José Ricardo de Arruda Miranda |
| Grantee: | Juliana Fernandes de Matos |
| Host Institution: | Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil |
| Associated research grant: | 10/07639-9 - Gastrointestinal motility: clinical investigations, physiopathology and biopharmaceutical, AP.TEM |
Abstract Several hormonal and physiological changes that occur during pregnancy seem to affect gastrointestinal motility (GI), however, very little is known about the relationship between the electrical and mechanical activities of the stomach and its implications. Animal studies show that progesterone has inhibitory effects on the gastrointestinal smooth musculature. Furthermore, progesterone decreases the tension of relaxation of gastric fundus and reduces the propagation speed of slow waves gastrointestinal possibly reduce the degree of electrical coupling between the smooth muscle cells, and the change in concentration of the hormone could be the possible cause of dysrhythmia and nausea in pregnancy.Diabetes mellitus is a public health problem worldwide and is often associated with symptoms and gastrointestinal motility disorders. In the literature, these disorders, particularly symptoms of delayed gastric emptying, have often been attributed to gastroparesis, developed as a result of diabetic autonomic neuropathy. About 70% of patients with diabetic gastroparesis and develop taquigastria bradigastria. Studies emphasize the importance of metabolic control of diabetes and its association with disorders that affect smooth muscle, neurons and cells of Cajal. Blood glucose control and insulin action also has a high importance, occurring risk of maternal death and malformations in the fetus. To obtain a faithful performance of metabolism of insulin in the body can be used, experimentally, a euglycemic clamp. This technique reproduces insulin sensitivity and functionality of pancreatic beta cells. As for this experiment have 2 aspects: the euglycemic clamp and hyperglycemic. The hyperglycemic clamp allows to analyze the insulin secretory response to glucose and quantify the consumption of the organism as a whole under constant conditions of hyperglycemia. Already euglycemic clamp allows the measurement of total glucose uptake in response to hyperinsulinemia constant.With this knowledge, aimed to compare the profile electrical, mechanical and hormonal pregnant rats with those observed in diabetic pregnancy and to evaluate the effects of glucose on gastric motility. For this we use the technique to measure biosusceptometria gastric contractility and electromyography to evaluate electrogastrography along with the electric log. These techniques are presented in an efficient and versatile evaluating gastric motility. | |
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