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Effect of cholecalciferol on TLR-7 and TLR-9 expression and IL-6 and INF-y production by Lymphocytes B in uremia

Grant number: 12/19314-2
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2012
Effective date (End): June 30, 2015
Field of knowledge:Health Sciences - Medicine
Principal researcher:Maria Aparecida Dalboni
Grantee:José Tarcísio Giffoni de Carvalho Júnior
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


Cardiovascular (CV) and infectious diseases remain the most common causes of mortality and morbidity, respectively among patients with chronic kidney disease (CKD). Previous studies have reported several alterations in immune cells, which contribute to increase incidence of CV and infectious diseases observed in this population. Biocompatibility of dialysis membrane and uremic toxins are the main factors associated with immune dysfunction in uremia. Furthermore, the Vitamin D deficiency is also associated with immunologic co-morbidities that are present in CKD. Vitamin D deficiency is highly prevalent among patients with all stages of CKD, but it is greater in peritoneal dialysis (PD) patients than the hemodialysis (HD) and pre-dialysis CKD patients. As the vitamin D receptor is expressed in the immune cells (B cells, T cells and others), and these cells are able to synthesizing the active vitamin D metabolite, many studies have investigated the role of vitamin D in the immune system. In this regard, previous studies have reported that vitamin D inhibits the TLR-induced cytokines production, including IFN-³ and IL-6. Thus, the purpose or this study is evaluate the effect of cholecalciferol treatment therapy on apoptosis, IFN-³ and IL-6 production, TLR-7 and TLR-9 expression in lymphocytes B in vitro and in vivo.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GIFFONI DE CARVALHO, JOSE TARCISIO; SCHNEIDER, MARION; CUPPARI, LILIAN; GRABULOSA, CAREN CRISTINA; CENDOROGLO, MIGUEL; DALBONI, MARIA APARECIDA. Cholecalciferol Supplementation Did Not Change Interleukin-7 and B cell-Activating Factor Levels and CD95 Expression in B lymphocytes in Patients on Dialysis: A Randomized Pilot-Controlled Trial. JOURNAL OF RENAL NUTRITION, v. 29, n. 5, p. 454-461, SEP 2019. Web of Science Citations: 1.
CARVALHO, JOSE TARCISIO G.; SCHNEIDER, MARION; CUPPARI, LILIAN; GRABULOSA, CAREN C.; AOIKE, DANILO T.; REDUBLO, BEATA MARIE Q.; BATISTA, MARCELO C.; CENDOROGLO, MIGUEL; MOYSES, ROSA MARIA; DALBONI, MARIA APARECIDA. Cholecalciferol decreases inflammation and improves vitamin D regulatory enzymes in lymphocytes in the uremic environment: A randomized controlled pilot trial. PLoS One, v. 12, n. 6 JUN 30 2017. Web of Science Citations: 10.

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