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Analysis of the effect of apocynin on the hipotensive responses induced by no donors in spontaneously hypertensive rats (SHR)

Grant number: 12/01733-9
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2013
Effective date (End): December 31, 2014
Field of knowledge:Biological Sciences - Pharmacology - Cardiorenal Pharmacology
Principal Investigator:Cristina Antoniali Silva
Grantee:Murilo Eduardo Graton
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


The chronic treatment with NADPH oxidase inhibitors reduces the SHR arterial pressure. Because it is the main superoxide anion source in the aorta, the activity of this enzyme is related with the decrease of the NO bioavailability. The purpose of this study will be to test the hypothesis that the treatment with apocynin (NADPH oxidase inhibitor) modifies the hypotensive effect of the acetylcholine and of the exogenous NO donors, in SHR. Normotensive Wistar rats and SHR will be treated with apocynin (30 mg/ kg/ day, p.o.) from the fourth to the tenth week of life. During the treatment, the systolic blood pressure will be verified by tail plethysmography. It will be made in vivo experiments for the evaluation of possible changes in the arterial blood pressure (mean, systolic and diastolic), heart rate and in the hypotensive responses stimulated by acetylcholine, TERPY, a new NO-donor, and sodium nitroprusside (SNP).(AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PERASSA, LIGIA A.; GRATON, MURILO E.; POTJE, SIMONE R.; TROIANO, JESSICA A.; LIMA, MARIANA S.; VALE, GABRIEL T.; PEREIRA, ARIANA A. F.; NAKAMUNE, ANA CLAUDIA M. S.; SUMIDA, DORIS H.; TIRAPELLI, CARLOS R.; et al. Apocynin reduces blood pressure and restores the proper function of vascular endothelium in SHR. VASCULAR PHARMACOLOGY, v. 87, p. 38-48, . (11/20998-0, 11/04619-0, 12/01733-9)

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