Thiocarbamoylpyrazole Palladium (II) complexes: synthesis, characterization and biological activity investigation

• Grant number: 12/23511-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2013
• End date: July 31, 2013
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Adelino Vieira de Godoy Netto
• Grantee: Thales Reggiani de Moura
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

This work deals with the synthesis, characterization, and cytotoxicity evaluation of chelated compounds of the type [PdX2(N;S)] and [Pd(N;S)2]Cl2 {N;S = N-substituted-1-thiocarbamoylpyrazoles; X=Cl, Br, I, SCN}. The compounds will be characterized by elemental analysis, IR and NMR spectroscopies, ESI/MS mass spectrometry, thermogravimetry (TG), and single crystal X-ray diffraction methods. The cytotoxicity of compounds towards normal cells and tumor cells sensitive and resistant to cisplatin will be determined by M.T.T. assay.(AU)