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Thiocarbamoylpyrazole palladium(II) complexes: synthesis, characterization and biological activity investigation

Grant number: 12/23511-8
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2013
Effective date (End): July 31, 2013
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Adelino Vieira de Godoy Netto
Grantee:Thales Reggiani de Moura
Home Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

This work deals with the synthesis, characterization, and cytotoxicity evaluation of chelated compounds of the type [PdX2(N;S)] and [Pd(N;S)2]Cl2 {N;S = N-substituted-1-thiocarbamoylpyrazoles; X=Cl, Br, I, SCN}. The compounds will be characterized by elemental analysis, IR and NMR spectroscopies, ESI/MS mass spectrometry, thermogravimetry (TG) and single crystal X-ray diffraction methods. The cytotoxicity of compounds towards normal cells and tumor cell sensitive and resistant to cisplatin will be determined by M.T.T. assay.