Evaluation of the effectiveness, cost and toxicity in the treatment of horses endoparasitoses using oral ivermectin in different presentations

• Grant number: 12/21596-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2013
• End date: January 31, 2014
• Field of knowledge: Agronomical Sciences - Veterinary Medicine
• Principal Investigator: José Nicolau Prospero Puoli Filho
• Grantee: Renan Rodrigues Modesto
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Parasitism is responsible for significant economic losses in the equine culture, on working, running, jumping, and breeding animals, causing diseases of clinical and health importance. Facing this, the present work has as main objective to evaluate comparatively the efficacy and cost-effectiveness of injectable ivermectin for cattle and oral gel paste for horses, both orally administered in horses naturally endoparasitized. 30 mongrel horses will be used, with varied weights and ages, divided into three groups. In group 1 (control) animals will receive orally 10 ml of saline 0.9% NaCl. Group 2 receives ivermectin oral gel paste at a dose of 0.2 mg/kg (oral ivermectin group) and animals in Group 3 will receive a bovine injectable 1% ivermectin, but orally administered, at doses of 0, 5 mg/kg.. Before and after treatment (0, 1, 7, 30, and 60) feces and blood samples will be collected for evaluation of the toxicity and effect of treatment. The development of research aims to improve the treatment of endoparasites in horses, taking into account the best cost-benefit for treatment.(AU)