Estimation of distribution algorithms for ab initio protein structure prediction

• Grant number: 13/00919-4
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: March 30, 2013
• End date: July 29, 2013
• Field of knowledge: Physical Sciences and Mathematics - Computer Science - Computer Systems
• Principal Investigator: Alexandre Cláudio Botazzo Delbem
• Grantee: Daniel Rodrigo Ferraz Bonetti
• Supervisor: Jochen Einbeck
• Host Institution: Instituto de Ciências Matemáticas e de Computação (ICMC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Institution abroad: Durham University (DU), England
• Associated to the scholarship: 10/02928-2 - Estimation of distributed algorithms for ab initio prediction of protein structures, BP.DR

Abstract

The student is in the development stage of the Estimation of Distribution Algorithm for Protein Structure Prediction (PSP). In order to generate related variables is necessary to use statistical techniques that are able to capture the dependence between continuous variables. Currently, this is being done using the method of Kernel. However, this method is computationally expensive. Therefore, it is expected studying new ways of estimating the joint probability of continuous variables. Thus, through contact with the Professor Jochen Einbeck, Durham University, England, it is expected, through an internship abroad, studying an alternative technique to estimate the joint probability, that could obtain quality predictions with less computational cost. (AU)