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Grant number: 12/24193-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2013
Effective date (End): October 31, 2016
Field of knowledge:Agronomical Sciences - Animal Husbandry
Principal Investigator:Antonio de Queiroz Neto
Grantee:Inaê Cristina Regatieri
Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Associated scholarship(s):14/20697-9 - Polymorphisms in candidate genes for athletic performance in Thoroughbred and Saddlebred horses, BE.EP.DR


In recent years, equine production has gained importance in the sports and leisure activities. The exportation of racehorses has been increasing and breeding techniques aiming to a better performance have become the desire of horse breeders. The study of muscle physiology associated to genetic improvement techniques can develop knowledge to improve equine breeds, although other factors can interfere on the development of the animals. Different training types applied to athlete horses can change physiological processes, e. g., homeostasis acid/base mechanisms ATP is the main fuel provided for muscle contraction to occur. One of the routes of ATP production is the anaerobic glycolysis whose final products, lactate and hydrogen ions, are responsible for muscle fatigue. Monocarboxylate transporters type 1 (MCT1) and its ancillary protein (CD147) have as function to transport H+ and lactate ions from plasma to red blood cells contributing to the maintenance of acid/base homeostasis retarding systemic acidosis and fatigue of glycolytic muscle fibers. Thus, the present project aims to exam the distribution of proteins MCT1 and CD147 on red blood cells of Arabian and Quarter Horses of high and low performance, identify polymorphisms of genes related to those proteins and verify if there is an association between the polymorphism and the expression of proteins on different breeds and performances, searching for possible alternatives to improve the performance of athlete horses.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
REGATIERI, INAE CRISTINA; MENDES ALMEIDA, MARIA LUIZA; TEIXEIRA NETO, ANTONIO RAPHAEL; CURI, ROGERIO ABDALLAH; FERRAZ, GUILHERME CAMARGO; QUEIROZ-NETO, ANTONIO. Quantification of MCT1 and CD147 in Red Blood Cells of Arabian and Quarter Horses. Journal of Equine Veterinary Science, v. 43, p. 66-71, . (12/24193-0, 11/11080-0, 14/20697-9)
REGATIERI, INAE CRISTINA; PEREIRA, GUILHERME LUIS; TEIXEIRA NETO, ANTONIO RAPHAEL; FERRAZ, GUILHERME CAMARGO; CURI, ROGERIO ABDALLAH; QUEIROZ-NETO, ANTONIO. Polymorphisms in MCT1, CD147, PDK4, and DMRT3 genes in Arabian and Quarter Horses. Journal of Equine Veterinary Science, v. 48, p. 161-165, . (12/24193-0, 14/20697-9)
INAÊ CRISTINA REGATIERI; ROGÉRIO ABDALLAH CURI; GUILHERME DE CAMARGO FERRAZ; ANTONIO DE QUEIROZ-NETO. Genes candidatos para desempenho em equinos, incluindo transportadores de monocarboxilatos. Pesquisa Veterinária Brasileira, v. 37, n. 1, p. 66-72, . (14/20697-9, 12/24193-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
REGATIERI, Inaê Cristina. Polymorphisms in candidate genes for athletic performance and quantification of MCT1 and CD147 in red blood cells of arabian and quarter horses. 2016. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.

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