Study of the expression of apoptotic genes, cell cycle, DNA repair and oxidative stress in cells of human lung carcinoma treated with complexes of formula [Ru(AA)(dppb) (4,4´-dimetylbipyridine)]PF6

• Grant number: 12/13042-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: April 01, 2013
• End date: November 30, 2013
• Field of knowledge: Physical Sciences and Mathematics - Chemistry
• Principal Investigator: Alzir Azevedo Batista
• Grantee: Regina Maria Mendes Oliveira
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

Researches have demonstrated that ruthenium complexes present great specificity and selectivity by tumor cells than compounds based on platin. Two ruthenium complexes (NAMI and NAMI-A) completed clinic fase I, both with low level of side effects. Several ruthenium complexes have been synthesized and studied by our research group, in the Department of Chemistry/UFSCar, presenting significant citotoxity against different tumor cell lines. Some of these compounds shown specificity against different types of tumor cells and most of them presented citotoxity higher than that of the cisplanin.Based on promising results already obtained by our research group in the Medicinal Inorganic Chemistry area and having in mind that different compounds with different structures can activate different way of cellular signaling we decided to synthesize compounds containing aminoacids, biological molecules, with general formula [Ru(AA)(dppb)(4,4´-dimetylbipyridine)]PF6 [AA = aminoacids; dppb = 1,4-bis(difenilfosfine) butane], and to study genes expression of apoptose cellular cyclic, DNA repair and oxidative stress in carcinoma cells of human lang treated with these complexes.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VELOZO-SA, VIVIANNE S.; OLIVEIRA, REGINA M. M.; LEITE, CELISNOLIA M.; COMINETTI, MARCIA R.; BARBOSA, ISABELY M. M.; SILVA, FABRICIO L. S.; FEITOSA, NATALIA MARTINS; SCHULTZ, MARIO S.; BATISTA, ALZIR A.. Scavenging capacity and cytotoxicity of new Ru(II)-diphosphine/α-amino acid complexes. Polyhedron, v. 201, p. 13-pg., 2021-04-05. (12/13042-0, 18/19342-2)