Resting state functional magnetic resonance imaging in patients with Parkinson Disease and impulsivity

• Grant number: 13/03358-3
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: September 02, 2013
• End date: March 01, 2014
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Fernando Cendes
• Grantee: Rachel Paes Guimarães
• Supervisor: Alain Dagher
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Institution abroad: McGill University, Montreal, Canada
• Associated to the scholarship: 11/19958-4 - Structural and functional conectivity analysis in Parkinsons Disease Patients, BP.DR

Abstract

Parkinson's disease is the second most common neurodegenerative disorder and it affects 17/100.000 worldwide. The main symptoms are resting tremor, bradykinesia, stiffness, freezing and postural instability. The symptoms usually begin in the fifth decade of life. Non motor symptoms have been recently identified in this patients, and they might be part of the natural course of the disease or due to medication. Among the non-motor symptoms, the most important are related to impulsivity.The main objective of the study is to assess brain abnormalities related to impulsivity in PD patients by means of rs-fMRI. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GUIMARAES, RACHEL P.; CAMPOS, BRUNNO M.; DE REZENDE, THIAGO J.; PIOVESANA, LUIZA; AZEVEDO, PAULA C.; AMATO-FILHO, AUGUSTO C.; CENDES, FERNANDO; D'ABREU, ANELYSSA. Is Diffusion Tensor Imaging a Good Biomarker for Early Parkinson's Disease?. FRONTIERS IN NEUROLOGY, v. 9, AUG 21 2018. (11/19958-4, 13/07559-3, 13/03358-3)

GUIMARAES, RACHEL PAES; ARCI SANTOS, MARIA CRISTINA; DAGHER, ALAIN; CAMPOS, LIDIANE SOARES; AZEVEDO, PAULA; PIOVESANA, LUIZA GONZAGA; DE CAMPOS, BRUNNO MACHADO; LARCHER, KEVIN; ZEIGHAMI, YASHAR; SCARPARO AMATO-FILHO, AUGUSTO C.; et al. Pattern of Reduced Functional Connectivity and Structural Abnormalities in Parkinson's Disease: An Exploratory Study. FRONTIERS IN NEUROLOGY, v. 7, JAN 13 2017. (13/03358-3, 11/19958-4, 12/05286-7)