Advanced search
Start date
Betweenand
Related content

IMMUNOPHENOTYPIC CHARACTERIZATION AND ANALYSIS OF GENE EXPRESSION PROFILING OF CANCER STEM CELL IN MULTIPLE MYELOMA, WITH FOCUS ON IDENTIFICATION OF POTENTIAL THERAPEUTIC TARGET

Grant number: 12/24614-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): March 01, 2013
Effective date (End): February 28, 2014
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Gisele Wally Braga Colleoni
Grantee:Fabio Pascutti
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated research grant:10/17668-6 - Identification of biomarkers and possible therapeutical targets in B-cell lymphoproliferative disorders, AP.TEM

Abstract

Multiple myeloma (MM) is highly responsive to high dose chemotherapy and autologous stem cell transplant. However, relapse remains a limiting factor for MM cure. One possible explanation for such a paradoxical scenario comes from the cancer stem cell (CSC) hypothesis, which is opposed to the stochastic model of tumorigenesis. In this mini review, we describe how CSCs were characterized in many cancers and, recently, in MM. A better understanding of the heterogeneity comprising tumor cells, including the important compartment of CSCs, is essential in the search for therapeutic targets that can effectively contribute to the decline in the risk of relapse and to the establishment of a cure for MM.