Pharmacological treatments of neurological disorders are often complicated due to the inability of the drugs to cross the blood brain barrier (BBB). The BBB, although essential for the maintenance of homeostasis of central nervous system (CNS), is the greatest obstacle to the access of therapeutic drugs in the neural microenvironment since it has structural and molecular characteristics that restrict the permeation of xenobiotics. In this context, nanotechnology may offer an innovative solution through the use of nanocarriers of genes, drugs or biomolecules. Among the different types of nanoparticles (NPs), carbon NPs, as graphene oxide (GO) are arguably the most interesting products of nanotechnology since their unique physicochemical characteristics provides a broad range of biological applications, including interface with neural systems components. Therefore the purpose of the present study is to investigate the ability of GO suspended in different vehicles (water and polyetilenoglycol) to cross the BBB in rats. The toxicity of both types of NPs in neural tissue will also be evaluated. Understanding the mechanisms involved may contribute to the development of useful tools for clinical intervention, and may be relevant for understanding the mechanisms related to the functioning of the BBB.
News published in Agência FAPESP Newsletter about the scholarship:
PADILHA MENDONCA, MONIQUE CULTURATO;
SOARES, EDILENE SIQUEIRA;
DE JESUS, MARCELO BISPO;
CERAGIOLI, HELDER JOSE;
IRAZUSTA, SILVIA PIERRE;
BATISTA, ANGELA GIOVANA;
RAMIREZ VINOLO, MARCO AURELIO;
MAROSTICA JUNIOR, MARIO ROBERTO;
DA CRUZ-HOFLING, MARIA ALICE.
Reduced graphene oxide: nanotoxicological profile in rats.
JOURNAL OF NANOBIOTECHNOLOGY,
JUN 24 2016.
Web of Science Citations: 15.