Proteomic characterization of exosomes and their inflammatory miRNAs from extravil...
| Grant number: | 12/24574-3 |
| Support type: | Scholarships in Brazil - Doctorate (Direct) |
| Effective date (Start): | April 01, 2013 |
| Effective date (End): | February 28, 2017 |
| Field of knowledge: | Biological Sciences - Pharmacology |
| Principal Investigator: | Victor Hugo Aquino Quintana |
| Grantee: | Muhammad Nawaz |
| Home Institution: | Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
Abstract Dengue is an infectious non-contagious disease caused by dengue viruses (DENV). About 50 to 100 million people are infected annually, making dengue a major public health concern especially in tropical and sub-tropical regions. Dengue has been recognized as a clinical entity since 1779, but up to now; the pathogenesis of infection is not completely understood. Currently, there are not available early laboratory markers that may indicate the risk of developing severe dengue. In the early hours of viral infection, the cytokines produced by cells that were infected or in contact with viral products, are vital in the conduct of the innate immune response. The infection of target cells such as dendritic cells, macrophages/monocytes, endothelial cells, neutrophils, fibroblasts, mast cells and hepatocytes in DENV infection, promotes a phenomenon known as "cytokine storm", highlighting the importance of these molecules in the pathogenesis of the disease. The aim of this study is to identify biomarkers of dengue with diagnostic and prognostic values, by determining the profile of cytokines in a panel of serum samples from dengue infected patients. The profile of cytokine will be determined by the cytokine microarray technology as well as by multi-analyte profiling beads (xMAP). (AU) | |