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Cytokine profile in dengue virus infection: identification of potential biomarkers for diagnosis and prognosis

Grant number: 12/24574-3
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): April 01, 2013
Effective date (End): February 28, 2017
Field of knowledge:Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
Principal researcher:Victor Hugo Aquino Quintana
Grantee:Muhammad Nawaz
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Dengue is an infectious non-contagious disease caused by dengue viruses (DENV). About 50 to 100 million people are infected annually, making dengue a major public health concern especially in tropical and sub-tropical regions. Dengue has been recognized as a clinical entity since 1779, but up to now; the pathogenesis of infection is not completely understood. Currently, there are not available early laboratory markers that may indicate the risk of developing severe dengue. In the early hours of viral infection, the cytokines produced by cells that were infected or in contact with viral products, are vital in the conduct of the innate immune response. The infection of target cells such as dendritic cells, macrophages/monocytes, endothelial cells, neutrophils, fibroblasts, mast cells and hepatocytes in DENV infection, promotes a phenomenon known as "cytokine storm", highlighting the importance of these molecules in the pathogenesis of the disease. The aim of this study is to identify biomarkers of dengue with diagnostic and prognostic values, by determining the profile of cytokines in a panel of serum samples from dengue infected patients. The profile of cytokine will be determined by the cytokine microarray technology as well as by multi-analyte profiling beads (xMAP). (AU)

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NAWAZ, MUHAMMAD; CAMUSSI, GIOVANNI; VALADI, HADI; NAZARENKO, IRINA; EKSTROM, KARIN; WANG, XIAOQIN; PRINCIPE, SIMONA; SHAH, NEELAM; ASHRAF, NAEEM M.; FATIMA, FARAH; et al. The emerging role of extracellular vesicles as biomarkers for urogenital cancers. NATURE REVIEWS UROLOGY, v. 11, n. 12, p. 688-701, . (12/24574-3)
RAMIREZ, MARCEL I.; AMORIM, MARIA G.; GADELHA, CATARINA; MILIC, IVANA; WELSH, JOSHUA A.; FREITAS, VANESSA M.; NAWAZ, MUHAMMAD; AKBAR, NAVEED; COUCH, YVONNE; MAKIN, LAURA; et al. Technical challenges of working with extracellular vesicles. NANOSCALE, v. 10, n. 3, p. 881-906, . (14/06863-3, 15/50257-3, 12/24574-3, 14/26897-0)
FATIMA, FARAH; EKSTROM, KARIN; NAZARENKO, IRINA; MAUGERI, MARCO; VALADI, HADI; HILL, ANDREW F.; CAMUSSI, GIOVANNI; NAWAZ, MUHAMMAD. Non-coding RNAs in Mesenchymal Stem Cell-Derived Extracellular Vesicles: Deciphering Regulatory Roles in Stem Cell Potency, Inflammatory Resolve, and Tissue Regeneration. FRONTIERS IN GENETICS, v. 8, . (12/24574-3)
STATELLO, LUISA; MAUGERI, MARCO; GARRE, ELENA; NAWAZ, MUHAMMAD; WAHLGREN, JESSICA; PAPADIMITRIOU, ALEXANDROS; LUNDQVIST, CHRISTINA; LINDFORS, LENNART; COLLEN, ANNA; SUNNERHAGEN, PER; et al. Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes. PLoS One, v. 13, n. 4, . (12/24574-3)
MATEESCU, BOGDAN; KOWAL, EMMA J. K.; VAN BALKOM, BAS W. M.; BARTEL, SABINE; BHATTACHARYYA, SUVENDRA N.; BUZAS, EDIT I.; BUCK, AMY H.; DE CANDIA, PAOLA; CHOW, FRANKLIN W. N.; DAS, SAUMYA; et al. Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper. JOURNAL OF EXTRACELLULAR VESICLES, v. 6, . (12/24574-3)
NAWAZ, MUHAMMAD; SHAH, NEELAM; ZANETTI, BRUNA RIEDO; MAUGERI, MARCO; SILVESTRE, RENATA NACASAKI; FATIMA, FARAH; NEDER, LUCIANO; VALADI, HADI. Extracellular Vesicles and Matrix Remodeling Enzymes: The Emerging Roles in Extracellular Matrix Remodeling, Progression of Diseases and Tissue Repair. CELLS, v. 7, n. 10, . (12/24574-3)
NAWAZ, MUHAMMAD; FATIMA, FARAH. Extracellular Vesicles, Tunneling Nanotubes, and Cellular Interplay: Synergies and Missing Links. FRONTIERS IN MOLECULAR BIOSCIENCES, v. 4, . (12/24574-3)

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