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Characterization of Annona coriacea extract action on the enzyme arginase from Leishmania amazonensis

Grant number: 12/20957-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2013
Effective date (End): September 30, 2015
Field of knowledge:Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
Principal researcher:Edson Roberto da Silva
Grantee:Lucas Corrêa da Silva Carrion
Home Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil

Abstract

Leishmaniasis is an anthropozoonosis that affects domestic dogs and humans. The dogs with leishmaniasis are sacrificed due to lack of proper treatment. The enzyme arginase of Leishmania is a validated target for developing drugs against the parasite. Our group works with medicinal plants that have activity in cultured parasite and inhibit the enzyme arginase. The plant Annona coriaceae has in vitro activity against promastigotes of L. (L.) amazonensis arginase and inhibits the parasite arginase enzyme. So we propose in this project to isolate inhibitors and to characterize biochemically the enzyme inhibitions by natural compounds from A. coriaceae. (AU)

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