Atorvastatin effects on diastolic funtion in ischemic and miocardic reperfusion model

• Grant number: 13/00063-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2013
• End date: December 31, 2013
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Orlando Petrucci Jr
• Grantee: Pedro Henrique Ramos Lopes
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Despite the improvement of the treatment of acute coronary syndromes the mortality and morbidity remain high in the clinical practice. The quantity of injuried cells during the primary ischemic event are the primary determinant of late outcome of acute myocardial infarction. The administration of statins within myocardial infarction period has been shown to reduce mortality and cardiovascular events by different mechanisms such as, atherosclerotic plaque stabilization by reduction of serum cholesterol reduction, and pleiotropic effects of platelet aggregation, inhibition of cell proliferation and migration, inflammatory effect and improvement in endothelial function. However, it is still controversial the role of statins in reducing ventricular remodeling after myocardial reperfusion. The purpose of this project is to determine whether administration of atorvastatin beginning 4 days prior to infarction, followed by another 4 weeks after the acute event attenuates the process of ventricular remodeling in relevant model of myocardial ischemia and reperfusion in rats. The primary aim of this study is to evaluate whether the use of atorvastatin may have beneficial effects on cardiac remodeling after 4 weeks of ischemia and reperfusion, demonstrated by diastolic function and left ventricle volumes assessed with pressure volume catheter. We hypothesized the use of atorvastatin in the peri infarction period may minimize loss of ventricular function and cellular damage in relevant model of ischemia/reperfusion injury. (AU)