Identification of signature selection in three lineages of Nellore cattle selected for growth

• Grant number: 12/24600-4
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): May 01, 2013
• Effective date (End): July 31, 2016
• Field of knowledge: Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
• Principal Investigator: Humberto Tonhati
• Grantee: Diercles Francisco Cardoso
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
• Associated research grant: 09/16118-5 - Genomic tools to genetic improvement of direct economic important traits in Nelore cattle, AP.TEM
• Associated scholarship(s): 14/13445-3 - Identification of signature of selection in three Nellore cattle lineages selected for growth, BE.EP.DR

Abstract

When genomic regions under influence of selection are identified, these regions are called selection signatures. Probably, the change of the genetic constitution is associated with the proximity of these regions with a potential QTL for the trait selected. So, this study has the aim to find selection signatures in Nellore cattle that can be used to identify QTLs. Firstly, it will be made a simulation study to determinate the probability of identification of the regions led to homozygosity randomly using two populations with the same size. After, will be use 678 animals belonging to experimental population raised in the Animal Science Experimental Station, divided in two herds; one is selected for yearling body weight and a not selected one (EEZS). The method used for signatures identification will be the comparison of Extended Haplotype Homozygosity between populations. The regions will be considered signature only in selected herds and related with the trait selected, while signature identified in both herds may be related to the breed standard or evolutionary history of the breed. The validating work of selection signatures will be done with a: comparison between signatures identified with two different methods; association study of the signatures more significant with phenotypic information; search for selection signatures identified in experimental population in an independent population and scan for QTL previously described for weight near signatures. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CARDOSO, DIERCLES F.; DE ALBUQUERQUE, LUCIA GALVAO; REIMER, CHRISTIAN; QANBARI, SABER; ERBE, MALENA; DO NASCIMENTO, ANDRE V.; VENTURINI, GUILHERME C.; BECKER SCALEZ, DAIANE C.; BALDI, FERNANDO; FERREIRA DE CAMARGO, GREGORIO M.; et al. Genome-wide scan reveals population stratification and footprints of recent selection in Nelore cattle. GENETICS SELECTION EVOLUTION, v. 50, MAY 2 2018. (09/16118-5, 14/13445-3, 12/24600-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CARDOSO, Diercles Francisco. Selection signatures in three lines of Nellore cattle selected for growth traits. 2016. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.