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Identification of signature selection in three lineages of Nellore cattle selected for growth

Grant number: 12/24600-4
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2013
Effective date (End): July 31, 2016
Field of knowledge:Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
Principal researcher:Humberto Tonhati
Grantee:Diercles Francisco Cardoso
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Associated research grant:09/16118-5 - Genomic tools to genetic improvement of direct economic important traits in Nelore cattle, AP.TEM
Associated scholarship(s):14/13445-3 - Identification of signature of selection in three Nellore cattle lineages selected for growth, BE.EP.DR

Abstract

When genomic regions under influence of selection are identified, these regions are called selection signatures. Probably, the change of the genetic constitution is associated with the proximity of these regions with a potential QTL for the trait selected. So, this study has the aim to find selection signatures in Nellore cattle that can be used to identify QTLs. Firstly, it will be made a simulation study to determinate the probability of identification of the regions led to homozygosity randomly using two populations with the same size. After, will be use 678 animals belonging to experimental population raised in the Animal Science Experimental Station, divided in two herds; one is selected for yearling body weight and a not selected one (EEZS). The method used for signatures identification will be the comparison of Extended Haplotype Homozygosity between populations. The regions will be considered signature only in selected herds and related with the trait selected, while signature identified in both herds may be related to the breed standard or evolutionary history of the breed. The validating work of selection signatures will be done with a: comparison between signatures identified with two different methods; association study of the signatures more significant with phenotypic information; search for selection signatures identified in experimental population in an independent population and scan for QTL previously described for weight near signatures. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Identificadas regiões genômicas que podem permitir aumento na produção de carne 
Identified genomic regions that might allow an increase in meat production 
Hallan regiones genómicas que podrían aumentar la producción de carne en Brasil 

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARDOSO, DIERCLES F.; DE ALBUQUERQUE, LUCIA GALVAO; REIMER, CHRISTIAN; QANBARI, SABER; ERBE, MALENA; DO NASCIMENTO, ANDRE V.; VENTURINI, GUILHERME C.; BECKER SCALEZ, DAIANE C.; BALDI, FERNANDO; FERREIRA DE CAMARGO, GREGORIO M.; ZERLOTTI MERCADANTE, MARIA E.; DO SANTOS GONCALVES CYRILLO, JOSLAINE N.; SIMIANER, HENNER; TONHATI, HUMBERTO. Genome-wide scan reveals population stratification and footprints of recent selection in Nelore cattle. GENETICS SELECTION EVOLUTION, v. 50, MAY 2 2018. Web of Science Citations: 3.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CARDOSO, Diercles Francisco. Assinaturas de seleção em três linhas de bovinos Nelore selecionados para características de crescimento. 2016. Doctoral Thesis - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências Agrárias e Veterinárias..

Please report errors in scientific publications list by writing to: cdi@fapesp.br.