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Effect of bicarbonate on mitophagy during ischemia/reperfusion

Grant number: 13/07292-7
Support type:Scholarships abroad - Research Internship - Doctorate (Direct)
Effective date (Start): July 08, 2013
Effective date (End): July 07, 2014
Field of knowledge:Biological Sciences - Biochemistry
Principal Investigator:Alicia Juliana Kowaltowski
Grantee:Bruno Barros Queliconi
Supervisor abroad: Roberta A. Gottlieb
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Local de pesquisa : San Diego State University, United States  

Abstract

Mitochondrial autophagy is one of the main processes that influence damage in ischemia/reperfusion. We have previously shown that bicarbonate increases ischemia/reperfusion injury and now hypothesize that the presence of bicarbonate may modulate mitochondrial autophagy by altering either the internal pH of the lysosome and/or the cell autophagy capacity leading to an increase in damaged mitochondria, which could increase ROS release and injury. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
QUELICONI, BRUNO B.; KOWALTOWSKI, ALICIA J.; GOTTLIEB, ROBERTA A. Bicarbonate Increases Ischemia-Reperfusion Damage by Inhibiting Mitophagy. PLoS One, v. 11, n. 12 DEC 14 2016. Web of Science Citations: 7.

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