| Grant number: | 13/07292-7 |
| Support type: | Scholarships abroad - Research Internship - Doctorate (Direct) |
| Effective date (Start): | July 08, 2013 |
| Effective date (End): | July 07, 2014 |
| Field of knowledge: | Biological Sciences - Biochemistry |
| Principal Investigator: | Alicia Juliana Kowaltowski |
| Grantee: | Bruno Barros Queliconi |
| Supervisor abroad: | Roberta A. Gottlieb |
| Home Institution: | Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Local de pesquisa : | San Diego State University, United States |
Abstract Mitochondrial autophagy is one of the main processes that influence damage in ischemia/reperfusion. We have previously shown that bicarbonate increases ischemia/reperfusion injury and now hypothesize that the presence of bicarbonate may modulate mitochondrial autophagy by altering either the internal pH of the lysosome and/or the cell autophagy capacity leading to an increase in damaged mitochondria, which could increase ROS release and injury. (AU) | |