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Effect of systemic inflammation following ischemia / reperfusion upon the visceral adipose tissue of mice

Grant number: 16/17640-0
Support type:Scholarships in Brazil - Master
Effective date (Start): June 01, 2017
Effective date (End): August 31, 2018
Field of knowledge:Biological Sciences - Pharmacology - General Pharmacology
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Alessandra Gambero
Grantee:Lígia Fernanda Ferraz
Home Institution: Universidade São Francisco (USF). Campus Bragança Paulista. Bragança Paulista , SP, Brazil

Abstract

Ischemia and reperfusion develops when there is an obstruction of blood vessels with subsequent restoration of flow, and its occurs in cases of myocardial ischemia, shock, trauma, hemorrhagic injury, surgery and transplantation. During hepatic ischemia, for example, there is production of free radicals that activate Kuppfer cells (macrophages residing in the liver) resulting in proinflammatory cytokines production. With reperfusion, neutrophils and macrophages are additionally recruited to the liver leading to an increased in the production of proinflammatory cytokines reaching the systemic circulation and triggering an inflammatory response that affects remote organs like lungs, kidneys, intestine, pancreas, adrenal and heart . Although it is well established that adipose tissue is inflamed during obesity and contributes to the establishment of a chronic low grade systemic inflammation, little is known about the effects of systemic inflammation on adipose tissue or if the pre-injured adipose tissue by obesity would respond the same way or if the adipose tissue also contribute to systemic inflammation that follows the injury of ischemia and reperfusion. Thus, this project aims to study the effects of systemic inflammation (injury by ischemia / reperfusion) on visceral adipose tissue in mice, evaluating the local inflammatory response (infiltration of leukocytes, expression of adhesion molecules, cytokine production) and the adipose tissue contribution to the maintenance of systemic inflammation. It is also intended to assess whether obese adipose tissue promote the same answers. (AU)

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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)