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Influence of subpopulations of lymphocytes and macrophages in the immune response of dogs with Visceral Leishmaniasis

Grant number: 13/00763-4
Support Opportunities:Scholarships in Brazil - Post-Doctorate
Effective date (Start): May 01, 2013
Effective date (End): March 16, 2016
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Principal Investigator:Rosemeri de Oliveira Vasconcelos
Grantee:Pamela Rodrigues Reina Moreira
Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil


The Visceral Leishmaniasis is a zoonosis whose etiological agent is the protozoan Leishmania. The immune response of dogs with Canine Visceral Leishmaniasis (CVL) is not yet fully elucidated. In dogs with CVL there is an imbalance between Th1 and Th2 and many organs are affected by the protozoan, inflammatory response or by the deposition of immune complexes. For this reason, in this study will be used 30 infected dogs, euthanized at the Center for Zoonosis Control form Araçatuba, endemic city for Leishmaniasis. One group of ten dogs, from non-endemic area for CVL, will be a control group. The main focus of this study will evaluate the predominant phenotype of macrophages (M1 and M2), T lymphocytes (CD3, CD4 and CD8) and associate these findings with the presence of plasma cells and the parasite load in different regions of the skin (ear and mirror nasal), lymph nodes (popliteal and subscapular), spleen and liver of animals infected and non-infected by Leishmania chagasi.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARQUES, NATALIA CASSARO; REINA MO REIRA, PAMELA RODRIGUES; LEAL BERTOLO, PAULO HENRIQUE; GAVA, FABIO NELSON; VASCONCELOS, ROSEMERI DE OLIVEIRA. Immunodetection of hepatic stellate cells in dogs with visceral leishmaniasis. Parasitology Research, v. 117, n. 6, p. 1829-1837, . (13/00763-4)
REINA MOREIRA, PAMELA RODRIGUES; FERNANDO, FILIPE SANTOS; MONTASSIER, HELIO JOSE; ANDRE, MARCOS ROGERIO; VASCONCELOS, ROSEMERI DE OLIVEIRA. Polarized M2 macrophages in dogs with visceral leishmaniasis. Veterinary Parasitology, v. 226, p. 69-73, . (13/00763-4)

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