|Support type:||Scholarships in Brazil - Post-Doctorate|
|Effective date (Start):||May 01, 2013|
|Effective date (End):||March 16, 2016|
|Field of knowledge:||Agronomical Sciences - Veterinary Medicine - Animal Pathology|
|Principal researcher:||Rosemeri de Oliveira Vasconcelos|
|Grantee:||Pamela Rodrigues Reina Moreira|
|Home Institution:||Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil|
The Visceral Leishmaniasis is a zoonosis whose etiological agent is the protozoan Leishmania. The immune response of dogs with Canine Visceral Leishmaniasis (CVL) is not yet fully elucidated. In dogs with CVL there is an imbalance between Th1 and Th2 and many organs are affected by the protozoan, inflammatory response or by the deposition of immune complexes. For this reason, in this study will be used 30 infected dogs, euthanized at the Center for Zoonosis Control form Araçatuba, endemic city for Leishmaniasis. One group of ten dogs, from non-endemic area for CVL, will be a control group. The main focus of this study will evaluate the predominant phenotype of macrophages (M1 and M2), T lymphocytes (CD3, CD4 and CD8) and associate these findings with the presence of plasma cells and the parasite load in different regions of the skin (ear and mirror nasal), lymph nodes (popliteal and subscapular), spleen and liver of animals infected and non-infected by Leishmania chagasi.