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Influence of Macrophage depletion in C57BL6 mouse Pubic Symphysis Remodeling during the late Pregnancy and Postpartum

Grant number: 12/25038-8
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): June 01, 2013
Effective date (End): February 28, 2015
Field of knowledge:Biological Sciences - Morphology - Histology
Principal Investigator:Paulo Pinto Joazeiro
Grantee:Bianca Gazieri Castelucci
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


SummaryThe pubic symphysis (PS) is part of the musculoskeletal system that supports the pelvic organs. In some models, such as mice and guinea pigs, this fibrocartilaginous junction is metabolically active during pregnancy and undergo by drastic changes hormonally regulated that result the formation of an elastic ligament (IpL) which facilitates the passage of the fetus during the delivery. The IpL also undergoes an extensive remodeling during pregnancy and presents similarities with uterine cervix regarding tissue composition, cell proliferation, and hormonal regulation by relaxin and steroid hormones. Although some findings showed that IpL relaxation behaves like a pro-inflammatory response, with participation of leukocytes, this process has not yet been fully explored in mice. In this study we purpose the characterization of aspects that involve the participation of leukocytes in mouse PS remodeling, employing the depletion of monocyte / macrophage, that will be exploit by tissue and cell morphological and gene expression analysis during relaxation (18 and 19 day of pregnancy) and the remodeling of PS at postpartum ( 1 and 3 days after delivery). If it is found that leukocytes do not act in relaxation of the mouse IpL, we hope to identify aspects of tissue remodeling that differ from pro-inflammatory responses, particularly in animal models (with employment of adults), which may contribute to the understanding of the homeostasis processes of the components of the birth canal and its supporters structures.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CASTELUCCI, BIANCA G.; CONSONNI, SILVIO R.; ROSA, VIVIANE S.; JOAZEIRO, PAULO P.. Recruitment of monocytes and mature macrophages in mouse pubic symphysis relaxation during pregnancy and postpartum recovery. BIOLOGY OF REPRODUCTION, v. 101, n. 2, p. 466-477, . (12/25038-8, 15/23616-2)
CASTELUCCI, BIANCA GAZIERI; CONSONNI, SILVIO ROBERTO; ROSA, VIVIANE SOUZA; SENSIATE, LUCIMARA APARECIDA; RUGNO DELATTI, PAULA CRISTINA; ALVARES, LUCIA ELVIRA; JOAZEIRO, PAULO PINTO. Time-dependent regulation of morphological changes and cartilage differentiation markers in the mouse pubic symphysis during pregnancy and postpartum recovery. PLoS One, v. 13, n. 4, . (12/25038-8, 15/23616-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CASTELUCCI, Bianca Gazieri. Influence of macrophage depletion in pubic symphysis remodeling of C57BL6 mice during late pregnancy and postpartum. 2015. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.

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