| Full text | |
| Author(s): |
Castelucci, Bianca Gazieri
[1]
;
Consonni, Silvio Roberto
[1]
;
Rosa, Viviane Souza
[1]
;
Sensiate, Lucimara Aparecida
[1]
;
Rugno Delatti, Paula Cristina
[1]
;
Alvares, Lucia Elvira
[1]
;
Joazeiro, Paulo Pinto
[1]
Total Authors: 7
|
| Affiliation: | [1] State Univ Campinas UNICAMP, Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | PLoS One; v. 13, n. 4 APR 5 2018. |
| Web of Science Citations: | 1 |
| Abstract | |
Animal models commonly serve as a bridge between in vitro experiments and clinical applications; however, few physiological processes in adult animals are sufficient to serve as proof-of-concept models for cartilage regeneration. Intriguingly, some rodents, such as young adult mice, undergo physiological connective tissue modifications to birth canal elements such as the pubic symphysis during pregnancy; therefore, we investigated whether the differential expression of cartilage differentiation markers is associated with cartilaginous tissue morphological modifications during these changes. Our results showed that osteochondral progenitor cells expressing Runx2, Sox9, Col2a1 and Dcx at the non-pregnant pubic symphysis proliferated and differentiated throughout pregnancy, giving rise to a complex osteoligamentous junction that attached the interpubic ligament to the pubic bones until labour occurred. After delivery, the recovery of pubic symphysis cartilaginous tissues was improved by the time-dependent expression of these chondrocytic lineage markers at the osteoligamentous junction. This process potentially recapitulates embryologic chondrocytic differentiation to successfully recover hyaline cartilaginous pads at 10 days postpartum. Therefore, we propose that this physiological phenomenon represents a proof-of-concept model for investigating the mechanisms involved in cartilage restoration in adult animals. (AU) | |
| FAPESP's process: | 12/25038-8 - Influence of Macrophage depletion in C57BL6 mouse Pubic Symphysis Remodeling during the late Pregnancy and Postpartum |
| Grantee: | Bianca Gazieri Castelucci |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 15/23616-2 - Characterization of monocytes and macrophages activation states present in the mouse pubic symphysis remodeling at late pregnancy and postpartum. |
| Grantee: | Paulo Pinto Joazeiro |
| Support Opportunities: | Regular Research Grants |