Diabetes Mellitus (DM) is defined as a metabolic disorder with complex origin, characterized by chronic hyperglycemia. It is a higly prevalent disease and it is considered a worldwide epidemic. Because of its complex origin and its various complications, it is of great importance to understand its progression for the development of new strategies for prevention and treatment.One of the methods that has been of enormous importance to such understanding is proteomics, a very promising field for the discovery of early biomarkers of various diseases. Biomarkers are substances that indicate normal or pathological biological states, which can be quantified and monitored. They are so great tools for diagnosis and prognosis of various diseases, and may even aid in prevention.This study involves the serpin family proteins (alpha-1-antitrypsin), the vitamin D binding protein and kininogen. Based on based on previous studies, these proteins have been involved in some way in the development of diabetes. Thios study aims to validate these proteins, which have potential for susceptibility biomarkers and/or progression of diabetes in non-obese diabetic mice (NOD). We hope they may become useful in the early diagnosis of diabetes and its complications.
News published in Agência FAPESP Newsletter about the scholarship: