ANDROGEN RECEPTOR CAG POLIMORFISM AND TELOMERE LENGTH IN PREMATURE OVARIAN FAILURE

• Grant number: 12/11069-9
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: June 01, 2013
• End date: May 31, 2016
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Rosana Maria dos Reis
• Grantee: Cristiana Libardi Miranda Furtado
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Premature ovarian failure (POF) is a heterogeneous disorder, clinically defined by permanent cessation of ovarian function before the age of 40 years, causing infertility. POF is a common condition affecting 1% of the female population and the diagnosis is established by amenorrhea, hypoestrogenism, and elevated FSH levels. The exact etiology is still unknown and may arise as secondary complications to order diseases or iatrogenic mechanisms, but in most cases it is idiopathic. Genetic and chromosome abnormalities are one of the most well known causes of POF, especially in X chromosome due to presence of essential genes for ovarian function. The Androgen Receptor gene (AR), located on the Xq11, is suggested as a marker for POF, because of its physiological role in ovarian development. The AR has a polymorphic repetitive DNA motif (CAGn) which is directly related to its expression, which has been inversely correlated with the AR function. Longer CAG repeat length can reduce the activity of the AR or even can silence the gene. The AR is proposed to have an association with telomeric proteins, playing a role in telomere stability, which is an important marker for cellular senescence that is lost with each cell division. In order to investigate the role of AR and telomere shortening in POF phenotype, and a possible correlation between these events, the present study aims to assess the repeat CAG polymorphism in the AR gene and telomere length in POF patients.

Scientific publications

(14)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SANTANA, VIVIANE PAIVA; MIRANDA-FURTADO, CRISTIANA LIBARDI; CHIELLI PEDROSO, DAIANA CRISTINA; EIRAS, MATHEUS CREDENDIO; CARNEIRO VASCONCELOS, MARIA APARECIDA; RAMOS, ESTER SILVEIRA; CALADO, RODRIGO TOCANTINS; FERRIANI, RUI ALBERTO; ESTEVES, SANDRO CASSIANO; DOS REIS, ROSANA MARIA. The relationship among sperm global DNA methylation, telomere length, and DNA fragmentation in varicocele: a cross-sectional study of 20 cases. SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE, v. 65, n. 2, p. 95-104, MAR 4 2019. (12/11069-9)

GIELEN, MARIJ; HAGEMAN, GEJA J.; ANTONIOU, EVANGELIA E.; NORDFJALL, KATARINA; MANGINO, MASSIMO; BALASUBRAMANYAM, MUTHUSWAMY; DE MEYER, TIM; HENDRICKS, AUDREY E.; GILTAY, ERIK J.; HUNT, STEVEN C.; et al. Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies. AMERICAN JOURNAL OF CLINICAL NUTRITION, v. 108, n. 3, p. 453-475, SEP 2018. (10/08800-8, 12/11566-2, 12/11069-9)

MIRANDA FURTADO, CRISTIANA LIBARDI; SALOMAO, KARINA BEZERRA; VERRUMA, CAROLINA GENNARI; PAULINO LEITE, SARAH BLIMA; LOPES RIOS, ALVARO FABRICIO; BIALECKA, MONIKA; MOUSTAKAS, IOANNIS; MEI, HAILIANG; PARO DE PAZ, CLAUDIA CRISTINA; DUARTE, GERALDO; et al. Variation in DNA methylation in the KvDMR1 (ICR2) region in first-trimester human pregnancies. Fertility and Sterility, v. 111, n. 6, p. 1186-1193, JUN 2019. (12/11069-9)

PEDROSO, DAIANA C. C.; SANTANA, VIVIANE P.; DONAIRES, FLAVIA S.; PICINATO, MARIA C.; GIORGENON, ROBERTA C.; SANTANA, BARBARA A.; PIMENTEL, RICARDO N.; KEEFE, DAVID L.; CALADO, RODRIGO T.; FERRIANI, RUI A.; et al. Telomere Length and Telomerase Activity in Immature Oocytes and Cumulus Cells of Women with Polycystic Ovary Syndrome. REPRODUCTIVE SCIENCES, v. 27, n. 6, JAN 2020. (12/11566-2, 12/11069-9)

FURTADO, CRISTIANA LIBARDI MIRANDA; IANNETTA, RENATA; FERRIANI, RUI ALBERTO; SILVA, ANA CAROLINA J. S.; MARTINELLI, CARLOS EDUARDO; CALADO, RODRIGO TOCANTINS; DOS REIS, ROSANA MARIA. Telomere length is not altered in girls with idiopathic central precocious puberty treated with a GnRH analog - leuprolide acetate. Gynecological Endocrinology, v. 36, n. 12, JUN 2020. (12/11566-2, 12/11069-9)

CAETANO, LISANDRA C.; VERRUMA, CAROLINA G.; PINAFFI, FABIO L., V; JARDIM, IZABELLE B.; FURTADO, GILVAN P.; SILVA, LUCIANO A.; FURTADO, CRISTIANA L. M.; DE SA ROSA-E-SILVA, ANA CAROLINA J.. In vivo and in vitro matured bovine oocytes present a distinct pattern of single-cell gene expression. ZYGOTE, v. 31, n. 1, p. 13-pg., 2022-10-20. (12/11069-9, 12/06068-3, 12/06006-8)

EIRAS, MATHEUS CREDENDIO; PINHEIRO, DANIEL PASCOALINO; ROMCY, KALIL ANDRADE MUBARAC; FERRIANI, RUI ALBERTO; DOS REIS, ROSANA MARIA; FURTADO, CRISTIANA LIBARDI MIRANDA. Polycystic Ovary Syndrome: the Epigenetics Behind the Disease. REPRODUCTIVE SCIENCES, v. 29, n. 3, p. 15-pg., 2021-04-07. (12/11069-9, 15/14031-0)

EIRAS, MATHEUS CREDENDIO; PINHEIRO, DANIEL PASCOALINO; ROMCY, KALIL ANDRADE MUBARAC; FERRIANI, RUI ALBERTO; DOS REIS, ROSANA MARIA; FURTADO, CRISTIANA LIBARDI MIRANDA. olycystic Ovary Syndrome: the Epigenetics Behind the Diseas. REPRODUCTIVE SCIENCES, v. 29, n. 3, APR 2021. (12/11069-9, 15/14031-0)

KOGURE, GISLAINE SATYKO; DA SILVA LARA, LUCIA ALVES; RIBEIRO, VICTOR BARBOSA; LOPES, IRIS PALMA; MENDES, MARIA CELIA; KODATO, SERGIO; FERRIANI, RUI ALBERTO; MIRANDA FURTADO, CRISTIANA LIBARDI; DOS REIS, ROSANA MARIA. Distinct Protocols of Physical Exercise May Improve Different Aspects of Well-being in Women With Polycystic Ovary Syndrome. AMERICAN JOURNAL OF LIFESTYLE MEDICINE, MAR 2021. (10/08800-8, 12/11069-9, 15/14031-0)

CAETANO, LISANDRA CRISTINA; MIRANDA-FURTADO, CRISTIANA LIBARDI; BATISTA, LUCIENE APARECIDA; PITANGUI-MOLINA, CAROLINE PALMIERI; HIGA, THAIS TIEMI; PADOVAN, CRISTIANA CAROLINA; JAPUR DE SA ROSA-E-SILVA, ANA CAROLINA. Validation of reference genes for gene expression studies in bovine oocytes and cumulus cells derived from in vitro maturation. ANIMAL REPRODUCTION, v. 16, n. 2, p. 290-296, APR-JUN 2019. (12/16444-2, 12/11069-9, 12/06068-3, 12/06006-8)

RIBEIRO, VICTOR BARBOSA; CHIELLI PEDROSO, DAIANA CRISTINA; KOGURE, GISLAINE SATYKO; LOPES, IRIS PALMA; SANTANA, BARBARA APARECIDA; DUTRA DE SOUZA, HUGO CELSO; FERRIANI, RUI ALBERTO; CALADO, RODRIGO TOCANTINS; MIRANDA FURTADO, CRISTIANA LIBARDI; DOS REIS, ROSANA MARIA. Short-Term Aerobic Exercise Did Not Change Telomere Length While It Reduced Testosterone Levels and Obesity Indexes in PCOS: A Randomized Controlled Clinical Trial Study. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 18, n. 21, NOV 2021. (15/14031-0, 12/11069-9, 19/17618-3)

MIRANDA-FURTADO, CRISTIANA L.; LUCHIARI, HELOISE R.; CHIELLI PEDROSO, DAIANA C.; KOGURE, GISLAINE S.; CAETANO, LISANDRA C.; SANTANA, BARBARA A.; SANTANA, VIVIANE P.; BENETTI-PINTO, CRISTINA L.; REIS, FERNANDO M.; MACIEL, MARIELLA A.; et al. Skewed X-chromosome inactivation and shorter telomeres associate with idiopathic premature ovarian insufficiency. Fertility and Sterility, v. 110, n. 3, p. 476+, AUG 2018. (12/11566-2, 12/11069-9)

FURTADO, CRISTIANA LIBARDI M.; RIBEIRO, VICTOR BARBOSA; PEDROSO, DAIANA C. C.; KOGURE, GISLAINE S.; FERRIANI, RUI A.; CALADO, RODRIGO T.; DOS REIS, ROSANA M.. CONTINUOUS AND INTERMITTENT AEROBIC TRAINING DID NOT CHANGE TELOMERE LENGTH, ALTHOUGH IT REDUCES HYPERANDROGENISM AND ANTROPOMETRIC INDEXES IN POLYCYSTIC OVARY SYNDROME.. Fertility and Sterility, v. 114, n. 3, p. 1-pg., 2020-09-01. (12/11069-9, 15/14031-0)

KOGURE, GISLAINE SATYKO; DA SILVA LARA, LUCIA ALVES; RIBEIRO, VICTOR BARBOSA; LOPES, IRIS PALMA; MENDES, MARIA CELIA; KODATO, SERGIO; FERRIANI, RUI ALBERTO; MIRANDA FURTADO, CRISTIANA LIBARDI; DOS REIS, ROSANA MARIA. Distinct Protocols of Physical Exercise May Improve Different Aspects of Well-being in Women With Polycystic Ovary Syndrome. AMERICAN JOURNAL OF LIFESTYLE MEDICINE, v. 17, n. 1, p. 12-pg., 2021-03-23. (12/11069-9, 10/08800-8, 15/14031-0)