Melatonin and its effect on the expression of angiogenic proteins in lineage of breast cancer

• Grant number: 13/08045-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2013
• End date: May 31, 2014
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Debora Aparecida Pires de Campos Zuccari
• Grantee: Gabriel Mandarini Doho
• Host Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil

Abstract

Breast cancer is considered the most common cancer in women, has tumor growth and metastasis, the major cause of evolution and death of patients. Tumor growth can lead to hypoxia in the tumor microenvironment and stimulate factors that induce the formation of new vessels by vasculogenesis and angiogenesis. Thus, molecules involved in this process are targets for new therapeutic agents. Some studies have shown that treatment with melatonin, a hormone secreted by the pineal gland, has oncostáticos effects, and can inhibit angiogenesis in some tumor types. The objective of this study is to evaluate in cell lines under hypoxic conditions and treated with melatonin, the expression of ten proteins involved in angiogenesis of breast cancer by Cytokine Antibody Array technique and cell viability by MTT assay. The data obtained in this study may confirm the potential value of melatonin as a therapeutic agent in breast cancer by reducing angiogenesis and thereby tumor progression. (AU)