Electrospinning of polymeric nanofibers of poly-acid lactic with incorporated titanium dioxide nanoparticles

• Grant number: 13/08341-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2013
• End date: September 29, 2015
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
• Principal Investigator: Anderson de Oliveira Lobo
• Grantee: Tatiane Venturott Toniato
• Host Institution: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil
• Associated research grant: 11/17877-7 - Development of new polymeric scaffolds by electrospinning technique with incorporation of vertically aligned carbon nanotubes and nanohidroxyapatite for bone tissue regeneration, AP.JP
• Associated scholarship(s): 14/16966-4 - Preparation of CoreShell structured PLA-Gelatin-TiO2 tri-component nanofibers by coaxial electrospinning, BE.EP.IC

Abstract

There is a significant need for materials that both prevent bacteria adhesion and rapidly form a strong bone-to-implant interface to achieve biomaterial stability. In this way, this project presents the novel poly(lactic acid)/TiO2 hybrid nanofibres that will be produced via electrospinning technique. TIO2 nanoparticles will be homogeneously dispersed and electrospun applied different voltages and collector's systems. Scanning electron microscopy, transmission electron microscopy, X-ray difractometry, X-ray dispersive spectroscopy and optical spectroscopy will be used to morphological and structural characterization. It is expected to obtain PLA/TiO2 hybrid nanofibers in order to obtain bone tissue regeneration. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TONIATTO, T. V.; RODRIGUES, B. V. M.; MARSI, T. C. O.; RICCI, R.; MARCIANO, F. R.; WEBSTER, T. J.; LOBO, A. O.. Nanostructured poly (lactic acid) electrospun fiber with high loadings of TiO2 nanoparticles: Insights into bactericidal activity and cell viability. Materials Science & Engineering C-Materials for Biological Applications, v. 71, p. 381-385, FEB 1 2017. (11/17877-7, 15/08523-8, 13/08341-1, 11/20345-7, 14/16966-4)